T
Tsaffrir Zor
Researcher at Tel Aviv University
Publications - 38
Citations - 2864
Tsaffrir Zor is an academic researcher from Tel Aviv University. The author has contributed to research in topics: Cytokine & Interleukin 10. The author has an hindex of 21, co-authored 38 publications receiving 2606 citations. Previous affiliations of Tsaffrir Zor include Life Sciences Institute & Hebrew University of Jerusalem.
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Journal ArticleDOI
Linearization of the Bradford Protein Assay Increases Its Sensitivity: Theoretical and Experimental Studies
Tsaffrir Zor,Zvi Selinger +1 more
TL;DR: Under standard assay conditions, the ratio of the absorbances, 590 nm over 450 nm, is strictly linear with protein concentration, and a linear equation that perfectly fits the experimental data is provided on the basis of mass action and Beer's law.
Journal ArticleDOI
Linearization of the Bradford Protein Assay
Orna Ernst,Tsaffrir Zor +1 more
TL;DR: It is shown that under standard assay conditions, the ratio of the absorbance measurements at 590 nm and 450 nm is strictly linear with protein concentration, and a linear equation developed on the basis of mass action and Beer's law perfectly fits the experimental data.
Journal ArticleDOI
Solution Structure of the KIX Domain of CBP Bound to the Transactivation Domain of c-Myb
TL;DR: Results from isothermal titration calorimetry and structural data point to a key difference between the two complexes in optimal pH for binding, as a result of differential pH-dependent interactions with histidine residues of KIX.
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Identification of small-molecule antagonists that inhibit an activator: coactivator interaction.
Jennifer L. Best,Carlos A. Amezcua,Bernhard M. Mayr,Lawrence Flechner,Christopher M. Murawsky,Beverly M. Emerson,Tsaffrir Zor,Kevin H. Gardner,Marc Montminy +8 more
TL;DR: The ability of small molecules to interfere with second-messenger signaling cascades by inhibiting specific protein-protein interactions in the nucleus is demonstrated by identifying several compounds that bind to different surfaces on KIX.
Journal ArticleDOI
Cooperativity in transcription factor binding to the coactivator CREB-binding protein (CBP). The mixed lineage leukemia protein (MLL) activation domain binds to an allosteric site on the KIX domain.
TL;DR: In this article, the authors characterized ternary complexes formed by the KIX domain of CBP and the transactivation domain of the trithorax group protein mixed lineage leukemia protein (MLL), together with either the phosphorylated kinase-inducible domain (pKID) or the activation domain from c-Myb.