Tsukasa Osaki

TL;DR: As horseshoe crab is a close relative of the spider, tachystatins and spider neurotoxins may have evolved from a common ancestral peptide, with adaptive functions.

TL;DR: ETD was used, in comparison to collision induced dissociation (CID), to identify endogenous peptides derived from secretory granules of a human endocrine cell line and this advantage was demonstrated in identifying a new antimicrobial peptide from neurosecretory protein VGF, VGF[554–577]-NH2, or in differentiating nearly isobaric peptides that arise from alternatively spliced exons of the gastrin-releasing peptide gene.

TL;DR: The results suggest that endogenous ANP and BNP play important roles in reparative vascular remodeling in ischemic tissue.

TL;DR: It is demonstrated that FXIII-B accelerates fibrin cross-linking and plays important roles in the formation of a ternary complex between proenzyme FXIII, prosubstrate fibr inogen, and activator thrombin.

TL;DR: This study exemplifies the impact of peptidomics to study naturally occurring peptides and identifies a novel intramolecular disulfide-linked 22-residue amidated peptide, designated AMP-IBP5, which showed antimicrobial activity against six of the eight microorganisms tested at concentrations comparable to or lower than those for well-characterized AMPs cathelicidin and β-defensin-2.