T
Tsukuru Umemura
Researcher at International University of Health and Welfare
Publications - 68
Citations - 1070
Tsukuru Umemura is an academic researcher from International University of Health and Welfare. The author has contributed to research in topics: Erythropoiesis & Bone marrow. The author has an hindex of 17, co-authored 65 publications receiving 976 citations. Previous affiliations of Tsukuru Umemura include International University, Cambodia & RMIT University.
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Journal ArticleDOI
Expression patterns of microRNAs 155 and 451 during normal human erythropoiesis.
TL;DR: Observations suggest that miR-155 and MiR-451 are key molecules for normal erythroid differentiation, and that quantitative assays of the two miRNAs may be a relevant method for analyzing pathological erythropoiesis.
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Thiazolidinedione Induces Apoptosis and Monocytic Differentiation in the Promyelocytic Leukemia Cell Line HL60
Nobuhisa Hirase,Toshihiko Yanase,Yi Ming Mu,Koichiro Muta,Tsukuru Umemura,Ryoichi Takayanagi,Hajime Nawata +6 more
TL;DR: The results suggest that the apoptotic or the differentiating effect of TZD on HL60 cells was synergistically enhanced by the combined treatment with 1 µM LG 100268, while LG100268 alone neither had an apoptotic nor a differentiates effect on HL 60 cells.
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Anemia and neutropenia in a case of copper deficiency: role of copper in normal hematopoiesis.
Nobuhisa Hirase,Yasunobu Abe,Shingo Sadamura,Yuji Yufu,Koichiro Muta,Tsukuru Umemura,Junji Nishimura,Hajime Nawata,Hiroshi Ideguchi +8 more
TL;DR: It is suggested that copper enzymes play an important role in the maturation of hematopoietic cells in patients with severe anemia and neutropenia after receiving parenteral nutrition for 2.5 years.
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Downregulation of plasma miR-451 and miR-16 in Plasmodium vivax infection.
Supat Chamnanchanunt,Chieri Kuroki,Varunee Desakorn,Mari Enomoto,Vipa Thanachartwet,Duangjai Sahassananda,Jetsumon Sattabongkot,Rachaneeporn Jenwithisuk,Suthat Fucharoen,Saovaros Svasti,Tsukuru Umemura,Tsukuru Umemura +11 more
TL;DR: Analysis of plasma miRNAs obtained from malaria patients and normal subjects suggests that plasma miR-451 and miR -16 are relevant biomarkers for malaria infection.
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Expression of microRNA-451 in normal and thalassemic erythropoiesis
Saovaros Svasti,Shizuka Masaki,Tipparat Penglong,Yasunobu Abe,Pranee Winichagoon,Suthat Fucharoen,Tsukuru Umemura +6 more
TL;DR: The results suggest that early erythroid progenitors in β-thalassemia have a dysregulated miRNA-451 expression program, and analysis of microRNA is a relevant approach to determine abnormalities of erythropoiesis.