T
Tsutomu Nishizawa
Researcher at American Hotel & Lodging Educational Institute
Publications - 38
Citations - 4775
Tsutomu Nishizawa is an academic researcher from American Hotel & Lodging Educational Institute. The author has contributed to research in topics: Hepatitis E virus & cDNA library. The author has an hindex of 19, co-authored 38 publications receiving 4629 citations. Previous affiliations of Tsutomu Nishizawa include Kyushu University & Jichi Medical University.
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Journal ArticleDOI
Molecular cloning and expression of human hepatocyte growth factor
Toshikazu Nakamura,Tsutomu Nishizawa,Mitchio Hagiya,Tatsuya Seki,Manabu Shimonishi,Atsushi Sugimura,Kosuke Tashiro,Shin Shimizu +7 more
TL;DR: The nucleotide sequence of the human HGF cDNA reveals that both α- andβ-chains are contained in a single open reading frame coding for a pre-pro precursor protein of 728 amino acids, which indicates that the activity of HGF is not species-specific.
Short Communication Sporadic acute or fulminant hepatitis E in Hokkaido, Japan, may be food-borne, as suggested by the presence of hepatitis E virus in pig liver as food
Yasuyuki Yazaki,Hitoshi Mizuo,Masaharu Takahashi,Tsutomu Nishizawa,Nobuhiko Sasaki,Yuhko Gotanda,Hiroaki Okamoto +6 more
TL;DR: In this article, the presence of hepatitis E virus (HEV) RNA by RT-PCR was found in packages of raw pig liver sold in grocery stores as food in Hokkaido.
Journal ArticleDOI
Germline gain-of-function mutations in RAF1 cause Noonan syndrome
M. Abdur Razzaque,Tsutomu Nishizawa,Yuta Komoike,Yuta Komoike,Hisato Yagi,Michiko Furutani,Ryunosuke Amo,Ryunosuke Amo,Mitsuhiro Kamisago,Kazuo Momma,Hiroshi Katayama,Masao Nakagawa,Yuko Fujiwara,Masaki Matsushima,Katsumi Mizuno,Mika Tokuyama,Hamao Hirota,Jun Muneuchi,Toru Higashinakagawa,Rumiko Matsuoka +19 more
TL;DR: In this article, the authors identify five different mutations in RAF1 in ten individuals with Noonan syndrome; those with any of four mutations causing changes in the CR2 domain of RAF1 had hypertrophic cardiomyopathy (HCM), whereas affected individuals with mutations leading to changes in CR3 domain did not.
Journal ArticleDOI
Deduced primary structure of rat hepatocyte growth factor and expression of the mRNA in rat tissues.
Kosuke Tashiro,Mitchio Hagiya,Tsutomu Nishizawa,Tatsuya Seki,Manabu Shimonishi,Shin Shimizu,Toshikazu Nakamura +6 more
TL;DR: The primary structure of rat hepatocyte growth factor (HGF) was elucidated by determining the base sequence of the complementary DNA (cDNA) of HGF by screening a liver cDNA library with oligonucleotides based on the partial N-terminal amino acid sequence ofthe beta subunit of purified rat HGF.
Journal ArticleDOI
Isolation and expression of cDNA for different forms of hepatocyte growth factor from human leukocyte.
Tatsuya Seki,Tatsuya Seki,Izumi Ihara,Izumi Ihara,Atsushi Sugimura,Atsushi Sugimura,Manabu Shimonishi,Manabu Shimonishi,Tsutomu Nishizawa,Tsutomu Nishizawa,Osamu Asami,Osamu Asami,Hagiya Michio,Hagiya Michio,Toshikazu Nakamura,Toshikazu Nakamura,Shin Shimizu,Shin Shimizu +17 more
TL;DR: Human leukocyte cDNA library was screened to isolate cDNA clones coding for hepatocyte growth factor using cDNA from human liver as a probe and both clones produced protein with similar biological activity against rat hepatocyte in vitro.