T
Tsuyoshi Nakai
Researcher at Nagoya University
Publications - 8
Citations - 250
Tsuyoshi Nakai is an academic researcher from Nagoya University. The author has contributed to research in topics: Astrocyte & Hippocampus. The author has an hindex of 5, co-authored 6 publications receiving 197 citations.
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Journal ArticleDOI
Nobiletin, a citrus flavonoid, ameliorates cognitive impairment, oxidative burden, and hyperphosphorylation of tau in senescence-accelerated mouse.
Akira Nakajima,Yuki Aoyama,Thuy Ty Lan Nguyen,Eun-Joo Shin,Hyoung-Chun Kim,Shinnosuke Yamada,Tsuyoshi Nakai,Taku Nagai,Akihito Yokosuka,Yoshihiro Mimaki,Yasushi Ohizumi,Yasushi Ohizumi,Yasushi Ohizumi,Kiyofumi Yamada +13 more
TL;DR: Evidence is presented that nobiletin improves age-related cognitive impairment and reduces oxidative stress and tau phosphorylation in SAMP8 mice and represents a potentially useful treatment for ameliorating the learning and memory deficits, oxidative stress, and hyperphosphorylation of tau in aging as well as age- related neurodegenerative diseases such as AD.
Journal ArticleDOI
Girdin phosphorylation is crucial for synaptic plasticity and memory : a potential role in the interaction of BDNF/TrkB/Akt signaling with NMDA receptor
Tsuyoshi Nakai,Taku Nagai,Motoki Tanaka,Norimichi Itoh,Naoya Asai,Atsushi Enomoto,Masato Asai,Shinnosuke Yamada,Ali Bin Saifullah,Masahiro Sokabe,Masahide Takahashi,Kiyofumi Yamada +11 more
TL;DR: The findings suggest that Girdin has two different functions in the hippocampus:Akt-independent neuronal migration and Akt-dependent NR2B phosphorylation through the interaction with Src, which is associated with synaptic plasticity in the hippocampal underlying memory formation.
Journal ArticleDOI
Alterations of GABAergic and dopaminergic systems in mutant mice with disruption of exons 2 and 3 of the Disc1 gene.
Tsuyoshi Nakai,Taku Nagai,Rui Wang,Shinnosuke Yamada,Keisuke Kuroda,Kozo Kaibuchi,Kiyofumi Yamada +6 more
TL;DR: The number of parvalbumin-positive interneurons, methamphetamine-induced DA release and the expression levels of GABAA, DA transporter (DAT) and DA receptors in wild-type and Disc1(Δ2-3/Δ 2-3) mice showed no apparent differences in all experiments, suggesting that DISC1 may play a critical role in gender-specific developmental alteration in GABAergic inhibitory interneuronons and DAergic neurons.
Journal ArticleDOI
Matrix metalloproteinase-3 is a possible mediator of neurodevelopmental impairment due to polyI:C-induced innate immune activation of astrocytes.
TL;DR: Results suggest that Mmp3 is a possible mediator of polyI:C-ACM-induced neurodevelopmental impairment.
Journal ArticleDOI
Alzheimer's Disease Animal Models: Elucidation of Biomarkers and Therapeutic Approaches for Cognitive Impairment.
TL;DR: In this article, a review assesses several Alzheimer's disease mouse models from the aspect of biomarkers and cognitive impairment and discusses their potential as tools to provide novel AD therapeutic approaches, but none of these models exhibit all pathologies present in human AD.