T
Tsuyoshi Takashima
Researcher at Hiroshima University
Publications - 11
Citations - 95
Tsuyoshi Takashima is an academic researcher from Hiroshima University. The author has contributed to research in topics: Cancer & Medicine. The author has an hindex of 4, co-authored 5 publications receiving 31 citations. Previous affiliations of Tsuyoshi Takashima include Osaka University.
Papers
More filters
Journal ArticleDOI
Molecular biological analysis of 5-FU-resistant gastric cancer organoids; KHDRBS3 contributes to the attainment of features of cancer stem cell
Shoichi Ukai,Ririno Honma,Naoya Sakamoto,Yusuke Yamamoto,Quoc Thang Pham,Kenji Harada,Tsuyoshi Takashima,Daiki Taniyama,Ryuichi Asai,Kaho Fukada,Kazuhito Naka,Kazuaki Tanabe,Hideki Ohdan,Wataru Yasui +13 more
TL;DR: GC organoids are established and KHDRBS3, which is thought to play an important role in the acquisition of characteristics of CSCs in GC, is found to be a promising candidate marker for predicting therapeutic effect and prognosis in GC patients.
Journal ArticleDOI
Immunohistochemical analysis of SLFN11 expression uncovers potential non-responders to DNA-damaging agents overlooked by tissue RNA-seq.
Tsuyoshi Takashima,Naoya Sakamoto,Junko Murai,Daiki Taniyama,Ririno Honma,Shoichi Ukai,Ryota Maruyama,Kazuya Kuraoka,Vinodh N. Rajapakse,Yves Pommier,Wataru Yasui +10 more
TL;DR: It is found that the SLFN11 expression is tissue specific and varies during tumorigenesis, and the significance of immunohistochemical procedures for evaluating expression of SLFN 11 in patient samples is revealed and provides a robust resource of SL FN11 expression across adult human organs.
Journal ArticleDOI
Schlafen 11 predicts response to platinum-based chemotherapy in gastric cancers.
Tsuyoshi Takashima,Tsuyoshi Takashima,Daiki Taniyama,Naoya Sakamoto,Maika Yasumoto,Ryuichi Asai,Takuya Hattori,Ririno Honma,Pham Quoc Thang,Shoichi Ukai,Ryota Maruyama,Kenji Harada,Kazuya Kuraoka,Kazuaki Tanabe,Atsuo T. Sasaki,Hideki Ohdan,Eiichi Morii,Junko Murai,Wataru Yasui +18 more
TL;DR: In this paper, the potential clinical utility of SLFN11 in the treatment of gastric cancer was investigated and the correlation between SLFN 11 expression and overall survival in 169 GC patients by an established immunohistochemical approach.
Journal ArticleDOI
Epigenetic suppression of SLFN11 in germinal center B-cells during B-cell development.
Fumiya Moribe,Momoko Nishikori,Tsuyoshi Takashima,Daiki Taniyama,Nobuyuki Onishi,Hiroshi Arima,Hiroyuki Sasanuma,Remi Akagawa,Fathi Elloumi,Shunichi Takeda,Yves Pommier,Eiichi Morii,Akifumi Takaori-Kondo,Junko Murai +13 more
TL;DR: In this article, the effects of two epigenetic modifiers, an EZH2 inhibitor, tazemetostat (EPZ6438), and a histone deacetylase inhibitor, panobinostat, LBH589, on SLFN11 expression in Germinal center B-cells (GCBs) during B-cell development were investigated.
Journal ArticleDOI
Uc.63+ contributes to gastric cancer progression through regulation of NF-kB signaling
Naoya Sakamoto,Yohei Sekino,Kaho Fukada,Quoc Thang Pham,Ririno Honma,Daiki Taniyama,Shoichi Ukai,Tsuyoshi Takashima,Takuya Hattori,Kazuhito Naka,Kazuaki Tanabe,Hideki Ohdan,Wataru Yasui +12 more
TL;DR: The results suggest that Uc.63+.63+ could be involved in GC progression by regulating GC cell growth and migration via NF-κB signaling through T-UCRs.