Tuan Leng Tay

TL;DR: An ImageJ plugin is presented that enables non-machine-learning experts to analyze their data with U-Net on either a local computer or a remote server/cloud service.

TL;DR: It is established that graft-derived macrophages acquire, over time, microglia characteristics, including ramified morphology, longevity, radio-resistance and clonal expansion, however, even after prolonged CNS residence, transcriptomes and chromatin accessibility landscapes of engrafted, BM-derived Macrophages remain distinct from yolk sac-derived host microglial.

TL;DR: A transcriptional atlas of myeloid subsets in experimental autoimmune encephalomyelitis (EAE), a mouse model of MS, shows that dendritic cells and monocyte-derived cells, but not resident macrophages, played a critical role by presenting antigen to pathogenic T cells, which may inform future therapeutic targeting strategies in MS.

TL;DR: The dynamic yet discrete self-organization of mature microglia in the healthy and diseased CNS is unravels and a new multicolor fluorescence fate mapping system is established to monitor microglial dynamics during steady state and disease.

TL;DR: A review of the emerging roles of microglia in brain development, plasticity and cognition, and discuss the implications of the depletion or dysfunction of micro-glia for our understanding of disease pathogenesis is presented in this paper.