Showing papers by "Tuhin Subhra Santra published in 2019"
University of Belgrade1, University of Padua2, Hospital Authority3, Shahid Beheshti University of Medical Sciences and Health Services4, University of Concepción5, North Eastern Regional Institute of Science and Technology6, University of Porto7, Indian Institute of Technology Madras8, Zabol University of Medical Sciences9
TL;DR: Liposomal cytarabine is a formulation with pronounced effectiveness in lymphomatous meningitis and reduced cardiotoxicity if compared to liposomal anthracyclines, which means its use could be extended to other diseases given its reduction in cytotoxic side effects compared to the free formulation.
Abstract: Cancer is the second leading cause of death worldwide. The main modality to fight against cancer is surgery, radiotherapy, and chemotherapy, and more recently targeted therapy, gene therapy and immunotherapy, which play important roles in treating cancer patients. In the last decades, chemotherapy has been well developed. Nonetheless, administration of the drug is not always successful, as limited drug dosage can reach the tumor cells.. In this context, the possibility to use an encapsulated anti-cancer drug may potentially solve the problem. Liposomal cytarabine is a formulation with pronounced effectiveness in lymphomatous meningitis and reduced cardiotoxicity if compared to liposomal anthracyclines. Thus, the future liposomal cytarabine use could be extended to other diseases given its reduction in cytotoxic side effects compared to the free formulation. This review summarizes the chemistry and biology of liposomal cytarabine, with exploration of its clinical implications.
40 citations
01 Dec 2019
TL;DR: The objective of this study is to develop a parallel intranuclear delivery method to obtain stable and homogeneous cells at 104 level using a laser irradiation optical system and a simple device.
Abstract: The objective of this study is to develop a parallel intranuclear delivery method to obtain stable and homogeneous cells at 104 level. A laser irradiation optical system and a simple device were fabricated for evaluation of basic characteristics. Nanosecond pulse laser was used to irradiate cells cultured on a titanium thin film using the laser irradiation optical system. The performance of the optical system was evaluated by cell viability assay. We examined the possibility of fluorescent molecules delivery to single cells.