T
Tuomo Hänninen
Researcher at University of Eastern Finland
Publications - 139
Citations - 13395
Tuomo Hänninen is an academic researcher from University of Eastern Finland. The author has contributed to research in topics: Dementia & Population. The author has an hindex of 48, co-authored 130 publications receiving 11889 citations. Previous affiliations of Tuomo Hänninen include University of Jyväskylä.
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Journal ArticleDOI
A 2 year multidomain intervention of diet, exercise, cognitive training, and vascular risk monitoring versus control to prevent cognitive decline in at-risk elderly people (FINGER): a randomised controlled trial
Tiia Ngandu,Tiia Ngandu,Jenni Lehtisalo,Alina Solomon,Alina Solomon,Esko Levälahti,Satu Ahtiluoto,Riitta Antikainen,Lars Bäckman,Tuomo Hänninen,Antti Jula,Tiina Laatikainen,Tiina Laatikainen,Jaana Lindström,Francesca Mangialasche,Teemu Paajanen,Satu Pajala,Markku Peltonen,Rainer Rauramaa,Anna Stigsdotter-Neely,Timo E. Strandberg,Timo E. Strandberg,Jaakko Tuomilehto,Hilkka Soininen,Miia Kivipelto +24 more
TL;DR: In the Finnish Geriatric Intervention Study to Prevent Cognitive Impairment and Disability (FINGER), a proof-of-concept randomised controlled trial, the authors aimed to assess a multidomain approach to prevent cognitive decline in at-risk elderly people from the general population.
Journal ArticleDOI
Midlife vascular risk factors and Alzheimer's disease in later life: longitudinal, population based study.
Miia Kivipelto,Eeva-Liisa Helkala,Mikko P. Laakso,Tuomo Hänninen,Merja Hallikainen,Kari Alhainen,Hilkka Soininen,Jaakko Tuomilehto,Aulikki Nissinen +8 more
TL;DR: Raised systolic blood pressure and high serum cholesterol concentration, and in particular the combination of these risks, in midlife increase the risk of Alzheimer's disease in later life.
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Apolipoprotein E epsilon4 allele, elevated midlife total cholesterol level, and high midlife systolic blood pressure are independent risk factors for late-life Alzheimer disease.
Miia Kivipelto,Eeva-Liisa Helkala,Mikko P. Laakso,Tuomo Hänninen,Merja Hallikainen,Kari Alhainen,Susan Iivonen,Arto Mannermaa,Jaakko Tuomilehto,Aulikki Nissinen,Hilkka Soininen +10 more
TL;DR: In this long-term, prospective population-based study, apoE, elevated total cholesterol level, and elevated systolic hypertension increased the risk for Alzheimer disease in an independent and additive manner.
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Hippocampus and entorhinal cortex in mild cognitive impairment and early AD
Corina Pennanen,Miia Kivipelto,Susanna Tuomainen,Päivi Hartikainen,Tuomo Hänninen,Mikko P. Laakso,Merja Hallikainen,Matti Vanhanen,Aulikki Nissinen,Eeva-Liisa Helkala,Pauli Vainio,Ritva Vanninen,Kaarina Partanen,Hilkka Soininen +13 more
TL;DR: The results suggest that the ERC atrophy precedes hippocampal atrophy in AD, and the E RC volume loss is dominant over the hippocampal volume loss in MCI, whereas more pronounced hippocampalVolume loss appears in mild AD.
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Hippocampal volumes in Alzheimer's disease, Parkinson's disease with and without dementia, and in vascular dementia An MRI study
Mikko P. Laakso,Kaarina Partanen,Paavo Riekkinen,Maarit Lehtovirta,Eeva-Liisa Helkala,Merja Hallikainen,Tuomo Hänninen,Pauli Vainio,H. Soininen +8 more
TL;DR: It is postulate that hippocampal atrophy does not seem to be a specific phenomenon of dementia in AD but also occurs in vascular dementia and PDD, and even in PD when no dementia is present, and coexistence of AD pathology in PD and VaD patients cannot be ruled out.