Turbe Hugues

Bio: Turbe Hugues is an academic researcher. The author has contributed to research in topics: Thiazepine. The author has an hindex of 2, co-authored 3 publications receiving 17 citations.

Process for the preparation of 11-amino-3-chloro-6,11-dihydro-5,5-dioxo-6-methyl-dibenzo[c,f][1,2]-thiazepine and application to the synthesis of tianeptine

Abstract: Synthesis of 11-amino-3-chloro-6,11-dihydro-5,5-dioxo-6-methyl dibenzo(c,f)(1,2)thiazepine (I) and its salts, from 3-chloro-6,11-dihydro-6-methyl-5,5,11-trioxo dibenzo(c,f)(1,2)thiazepine (III). Synthesis of 11-amino-3-chloro-6,11-dihydro-5,5-dioxo-6-methyl dibenzo(c,f)(1,2)thiazepine of formula (I) and its salts, from 3-chloro-6,11-dihydro-6-methyl-5,5,11-trioxo dibenzo(c,f)(1,2)thiazepine of formula (III): Independent claims are also included for the use of (I) to prepare tianeptine (II) and its salts.

Process for the preparation of 11-amino-3-chloro-6, 11-dihydro-5, 5-dioxo-6-methyl-dibenzo&lsqb c,f&rsqb &lsqb 1,2&rsqb thiazepine and application to the synthesis of tianeptine

Abstract: Process for the industrial synthesis of the compound of formula (I): and its addition salts.Application to the synthesis of tianeptine and its pharmaceutically acceptable salts.

NOUVEAU PROCEDE DE PREPARATION DE LA 11-AMINO-3-CHLORO-6,11- DIHYDRO-5,5-DIOXO-6-METHYL-DIBENZO[c,f][1,2]-THIAZEPINE ET APPLICATION A LA SYNTHESE DE LA TIANEPTINE

Abstract: Procede de synthese industrielle du compose de formule (I) : (CF DESSIN DANS BOPI) et de ses sels d'addition. Application a la synthese de la tianeptine et de ses sels pharmaceutiquement acceptables.

Compositions and methods for treatment of irritable bowel syndrome and nonulcer dyspepsia

Abstract: Compounds according to the formula as defined herein are administered for the treatment of irritable bowel syndrome and nonulcer dyspepsia.

Process and intermediates for the preparation of 7-((3-chloro-6-methyl-5,5-dioxo-6,11-dihydrodibenzo(c,f)(1,2) thiazepin-11-yl)amino)heptanoate

Abstract: The present invention relates to a novel process for the preparation of sodium 7-((3-Chloro-6-methyl-5,5-dioxo-6,11-dihydrodibenzo(c,f)(1,2)thiazepin-11-yl)amino)heptanoate and intermediates. The invention also encompasses isolation of an essentially non-hygroscopic compound which is substantially pure.

Method for treating neurocognitive dysfunction

Abstract: A method of treating corticosteroid-induced cognitive impairment comprises administering an effective amount of at least one compound of formula I, or pharmaceutically acceptable salts thereof, to a subject in need of such treatment. Formula I is: wherein: A is a bridge selected from the following radicals: —(CH2)m—, —CH═CH—, —(CH2)p—O—, —(CH2)p—S—, —(CH2)p—SO2—, —(CH2)p—NR1— and —SO2—NR2—, and wherein: m is an integer of from 1 to 3 inclusive; p is an integer selected from 1 and 2; R1 is selected from the group consisting of hydrogen and C1-C5 alkyl; and R2 is C1-C5 alkyl; X and Y are independently selected from the group consisting of hydrogen and halogen; R and R′ are independently selected from the group consisting of hydrogen and C1-C5 alkyl; n is an integer from 1 to 12 inclusive; and * denotes an asymmetric carbon.

Mitragynine alkaloids as opioid receptor modulators

Abstract: The present invention provides a compound having the structure: or a pharmaceutically acceptable salt or ester thereof, and a method of treating a subject afflicted with pain, a depressive disorder, a mood disorder or an anxiety disorder by administering the compound to the subject.

Tianeptine sulfate salt forms and methods of making and using the same

Abstract: Disclosed herein is a novel sulfate salt of tianeptine with improved properties. Also described herein are novel pharmaceutical compositions comprising tianeptine sulfate salt, methods of making, and related methods of treatment.