T
Tyler N. Starr
Researcher at Fred Hutchinson Cancer Research Center
Publications - 61
Citations - 8070
Tyler N. Starr is an academic researcher from Fred Hutchinson Cancer Research Center. The author has contributed to research in topics: Epitope & Biology. The author has an hindex of 20, co-authored 37 publications receiving 3209 citations. Previous affiliations of Tyler N. Starr include Willamette University & Howard Hughes Medical Institute.
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Journal ArticleDOI
Deep Mutational Scanning of SARS-CoV-2 Receptor Binding Domain Reveals Constraints on Folding and ACE2 Binding.
Tyler N. Starr,Allison J. Greaney,Allison J. Greaney,Sarah K Hilton,Sarah K Hilton,Daniel Ellis,Katharine H.D. Crawford,Katharine H.D. Crawford,Adam S. Dingens,Mary Jane Navarro,John E. Bowen,M. Alejandra Tortorici,Alexandra C. Walls,Neil P. King,David Veesler,Jesse D. Bloom,Jesse D. Bloom,Jesse D. Bloom +17 more
TL;DR: It is found that a substantial number of mutations to the RBD are well tolerated or even enhance ACE2 binding, including at ACE2 interface residues that vary across SARS-related coronaviruses.
Journal ArticleDOI
Comprehensive mapping of mutations in the SARS-CoV-2 receptor-binding domain that affect recognition by polyclonal human plasma antibodies.
Allison J. Greaney,Allison J. Greaney,Andrea N. Loes,Andrea N. Loes,Katharine H.D. Crawford,Katharine H.D. Crawford,Tyler N. Starr,Tyler N. Starr,Keara D. Malone,Helen Y. Chu,Jesse D. Bloom,Jesse D. Bloom +11 more
TL;DR: In this article, the authors map how convalescent plasma antibodies are impacted by all mutations to the spike's receptor-binding domain (RBD), the main target of plasma neutralizing activity.
Journal ArticleDOI
Complete Mapping of Mutations to the SARS-CoV-2 Spike Receptor-Binding Domain that Escape Antibody Recognition.
Allison J. Greaney,Allison J. Greaney,Tyler N. Starr,Pavlo Gilchuk,Seth J. Zost,Elad Binshtein,Andrea N. Loes,Andrea N. Loes,Sarah K Hilton,John Huddleston,Rachel Eguia,Katharine H.D. Crawford,Katharine H.D. Crawford,Adam S. Dingens,Rachel S. Nargi,Rachel E. Sutton,Naveenchandra Suryadevara,Paul W. Rothlauf,Paul W. Rothlauf,Zhuoming Liu,Sean P. J. Whelan,Robert H. Carnahan,Robert H. Carnahan,James E. Crowe,James E. Crowe,Jesse D. Bloom,Jesse D. Bloom,Jesse D. Bloom +27 more
TL;DR: A deep mutational scanning method is described to map how all amino-acid mutations in the RBD affect antibody binding, and this method is applied to 10 human monoclonal antibodies to enable rational design of antibody therapeutics and assessment of the antigenic consequences of viral evolution.
Journal ArticleDOI
Prospective mapping of viral mutations that escape antibodies used to treat COVID-19.
Tyler N. Starr,Allison J. Greaney,Allison J. Greaney,Amin Addetia,Amin Addetia,William W. Hannon,William W. Hannon,Manish Chandra Choudhary,Adam S. Dingens,Jonathan Z. Li,Jesse D. Bloom,Jesse D. Bloom,Jesse D. Bloom +12 more
TL;DR: In this article, the authors map how all mutations to the receptor binding domain (RBD) of SARS-CoV-2 affect binding by the antibodies in the REGN-COV2 cocktail and the antibody LYCoV016.
Journal ArticleDOI
Epistasis in protein evolution
TL;DR: An emerging picture of pervasive epistasis is described in which the physical and biological effects of mutations change over the course of evolution in a lineage‐specific fashion, making evolution more contingent on low‐probability historical events and leaves stronger marks on the sequences, structures, and functions of protein families.