T
Tyler P. Rasmussen
Researcher at Roy J. and Lucille A. Carver College of Medicine
Publications - 14
Citations - 1873
Tyler P. Rasmussen is an academic researcher from Roy J. and Lucille A. Carver College of Medicine. The author has contributed to research in topics: Uniporter & Heart rate. The author has an hindex of 7, co-authored 13 publications receiving 1780 citations. Previous affiliations of Tyler P. Rasmussen include University of Iowa Hospitals and Clinics & University of Iowa.
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Journal ArticleDOI
Correction: Corrigendum: The mitochondrial uniporter controls fight or flight heart rate increases
Yuejin Wu,Tyler P. Rasmussen,Olha M. Koval,Mei-ling A. Joiner,Duane D. Hall,Biyi Chen,Elizabeth D. Luczak,Qiongling Wang,Adam G. Rokita,Xander H.T. Wehrens,Long-Sheng Song,Mark E. Anderson +11 more
TL;DR: In Fig. 4c of this Article, the y axis values were wrongly given as 0, 20, 40, 60 and 80 in the middle and the lower panels.
Journal ArticleDOI
Corrigendum: The mitochondrial uniporter controls fight or flight heart rate increases
Yuejin Wu,Tyler P. Rasmussen,Olha M. Koval,Mei Ling A. Joiner,Duane D. Hall,Biyi Chen,Elizabeth D. Luczak,Qiongling Wang,Adam G. Rokita,Xander H.T. Wehrens,Long-Sheng Song,Mark E. Anderson +11 more
TL;DR: In this paper, the y axis values were wrongly given as 0, 20, 40, 60 and 80 in the middle and the lower panels, respectively, in Fig. 4c of this article.
Journal ArticleDOI
Inhibition of MCU forces extramitochondrial adaptations governing physiological and pathological stress responses in heart
Tyler P. Rasmussen,Yuejin Wu,Mei-ling A. Joiner,Olha M. Koval,Nicholas R. Wilson,Elizabeth D. Luczak,Qinchuan Wang,Biyi Chen,Zhan Gao,Zhiyong Zhu,Brett A. Wagner,Jamie Soto,Michael L. McCormick,William J. Kutschke,Robert M. Weiss,Liping Yu,Ryan L. Boudreau,E. Dale Abel,Fenghuang Zhan,Douglas R. Spitz,Garry R. Buettner,Long-Sheng Song,Leonid V. Zingman,Mark E. Anderson +23 more
TL;DR: It is shown that chronic myocardial MCU inhibition leads to previously unanticipated compensatory changes that affect cytoplasmic Ca2+ homeostasis, reprogram transcription, increase OCR, reduce performance, and prevent anticipated therapeutic responses to ischemia-reperfusion injury.
Journal ArticleDOI
The mitochondrial uniporter controls fight or flight heart rate increases
Yuejin Wu,Tyler P. Rasmussen,Olha M. Koval,Mei Ling A. Joiner,Duane D. Hall,Biyi Chen,Elizabeth D. Luczak,Qiongling Wang,Adam G. Rokita,Xander H.T. Wehrens,Long-Sheng Song,Mark E. Anderson +11 more
TL;DR: This work found MCU function was essential for rapidly increasing mitochondrial calcium in pacemaker cells and that MCU enhanced oxidative phoshorylation was required to accelerate loading of an intracellular calcium compartment prior to each heartbeat.
Journal ArticleDOI
Loss of MCU prevents mitochondrial fusion in G1-S phase and blocks cell cycle progression and proliferation.
Olha M. Koval,Emily K. Nguyen,Velarchana Santhana,Trevor P. Fidler,Trevor P. Fidler,Sara C. Sebag,Tyler P. Rasmussen,Dylan J. Mittauer,Stefan Strack,Prabhat C. Goswami,E. Dale Abel,Isabella M. Grumbach +11 more
TL;DR: The mitochondrial Ca2+ uniporter enables ATP production to match energy demands during the cell cycle and highlights a key function for the MCU in mitochondrial adaptation to the metabolic demands during cell cycle progression.