T
Tyler R. Simpson
Researcher at University of Texas MD Anderson Cancer Center
Publications - 15
Citations - 5384
Tyler R. Simpson is an academic researcher from University of Texas MD Anderson Cancer Center. The author has contributed to research in topics: T cell & Cytotoxic T cell. The author has an hindex of 9, co-authored 13 publications receiving 4413 citations. Previous affiliations of Tyler R. Simpson include Howard Hughes Medical Institute & Memorial Sloan Kettering Cancer Center.
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Journal ArticleDOI
Depletion of Carcinoma-Associated Fibroblasts and Fibrosis Induces Immunosuppression and Accelerates Pancreas Cancer with Reduced Survival.
Berna C. Özdemir,Berna C. Özdemir,Tsvetelina Pentcheva-Hoang,Julienne L. Carstens,Xiaofeng Zheng,Chia Chin Wu,Tyler R. Simpson,Hanane Laklai,Hikaru Sugimoto,Hikaru Sugimoto,Christoph Kahlert,Christoph Kahlert,Sergey V. Novitskiy,Ana De Jesus-Acosta,Padmanee Sharma,Pedram Heidari,Umar Mahmood,Lynda Chin,Harold L. Moses,Valerie M. Weaver,Anirban Maitra,James P. Allison,Valerie S. LeBleu,Valerie S. LeBleu,Raghu Kalluri,Raghu Kalluri +25 more
TL;DR: Although myofibroblast-depleted tumors did not respond to gemcitabine, anti-CTLA4 immunotherapy reversed disease acceleration and prolonged animal survival, and underscores the need for caution in targeting carcinoma-associated fibroblasts in PDAC.
Journal ArticleDOI
Fc-dependent depletion of tumor-infiltrating regulatory T cells co-defines the efficacy of anti-CTLA-4 therapy against melanoma.
Tyler R. Simpson,Fubin Li,Welby Montalvo-Ortiz,Manuel A. Sepulveda,Katharina Bergerhoff,Frederick Arce,Claire Roddie,Jake Y. Henry,Hideo Yagita,Jedd D. Wolchok,Karl S. Peggs,Jeffrey V. Ravetch,James P. Allison,Sergio A. Quezada +13 more
TL;DR: Anti–CTLA-4 antibody induces selective depletion of T reg cells within tumor lesions in a manner that is dependent on the presence of Fc gamma receptor-expressing macrophages within the tumor microenvironment.
Journal ArticleDOI
Tumor-reactive CD4+ T cells develop cytotoxic activity and eradicate large established melanoma after transfer into lymphopenic hosts
Sergio A. Quezada,Tyler R. Simpson,Karl S. Peggs,Taha Merghoub,Jelena Vider,Xiaozhou Fan,Ronald G. Blasberg,Hideo Yagita,Pawel Muranski,Paul A. Antony,Nicholas P. Restifo,James P. Allison +11 more
TL;DR: It is found that transfer of small numbers of naive tumor-reactive CD4+ T cells into lymphopenic recipients induces substantial T cell expansion, differentiation, and regression of large established tumors without the need for in vitro manipulation.
Journal ArticleDOI
Erratum to Depletion of Carcinoma-Associated Fibroblasts and Fibrosis Induces Immunosuppression and Accelerates Pancreas Cancer with Reduced Survival [Cancer Cell 25, 719-734; (2014)]
Berna C. Özdemir,Tsvetelina Pentcheva-Hoang,Julienne L. Carstens,Xiaofeng Zheng,Chia Chin Wu,Tyler R. Simpson,Hanane Laklai,Hikaru Sugimoto,Christoph Kahlert,Sergey V. Novitskiy,Ana De Jesus-Acosta,Padmanee Sharma,Pedram Heidari,Umar Mahmood,Lynda Chin,Harold L. Moses,Valerie M. Weaver,Anirban Maitra,James P. Allison,Valerie S. LeBleu,Raghu Kalluri +20 more
TL;DR: This research highlights the need to understand more fully the role of language in the development of post-traumatic stress disorder and the role that language can play in the recovery.
Journal ArticleDOI
Shifting the equilibrium in cancer immunoediting: from tumor tolerance to eradication.
TL;DR: In this article, the authors discuss relevant work focusing on the establishment of the intratumor balance, the dynamic changes in the populations of effector and regulatory T cells within the tumor, and the role of the tumor vasculature and its activation state in the recruitment of different T-cell subsets.