U. P. Patil

Bio: U. P. Patil is an academic researcher from Shivaji University. The author has contributed to research in topics: Catalysis & Schiff base. The author has an hindex of 5, co-authored 9 publications receiving 101 citations.

Natural Acid Catalyzed Synthesis of Schiff under Solvent-Free Condition: As a Green Approach

Abstract: The reaction of primary aromatic amines with aryl aldehydes is found to be catalyzed by lemon juice as natural acid under solvent-free conditions to give the corresponding Schiff bases in good yields. This eco-friendly reaction has many advantages like economical, environmental, mild reaction conditions and simple work-up with high product yield.

Natural Acid Catalyzed Synthesis of Schiff Base under Solvent-free Condition: As a Green Approach

Abstract: The reaction of primary aromatic amines with aryl aldehydes is found to be catalyzed by lemon juice as natural acid under solvent-free conditions to give the corresponding Schiff bases in good yields. This eco-friendly reaction has many advantages like economical, environmental, mild reaction conditions and simple work-up with high product yield.

Ash of pomegranate peels (APP): A bio-waste heterogeneous catalyst for sustainable synthesis of α,α′-bis(substituted benzylidine)cycloalkanones and 2-arylidene-1-tetralones

Abstract: α,α′-bis(substituted benzylidene)cycloalkanones were efficiently prepared from variously substituted aldehydes and cycloalkanones in water by using ash of pomegranate peels (APP) as a catalyst. The APP-catalyst was obtained from bio-waste by simple thermal treatment to dry peels of pomegranate fruit and formation of its active phase was confirmed by FT-IR, XRD, XRF, EDX, SEM, DSC-TGA and BET techniques. The analysis revealed that the present catalyst has basic sites which promote the synthesis of desired products. The main attractions of our protocol are utilization of highly abundant bio-waste-derived catalyst and good-to-excellent yield in shortest reaction time. This green protocol was further extended for structurally diverse 2-arylidene-1-tetralones by condensation of equimolar quantity of aromatic aldehydes and 1-tetralone at low temperature. The catalyst could be quantitatively recovered and reused effectively for five times.

A synergetic role of Aegle marmelos fruit ash in the synthesis of biscoumarins and 2-amino-4H-chromenes

Abstract: A dry rind of Aegle marmelos (bael) fruit ash as a synergetic alternative material to an expensive, toxic and corrosive catalysts for the synthesis of biscoumarins and 2-amino-4H-chromenes at ambient temperature in water is reported. The spectroscopic evidence from EDX, FTIR, XRD and SEM analysis of bael fruit ash supports the presence of metal oxides, carbonates and hydroxides which are intensely responsible for the acceleration of the reactions. The striking features of this protocol are utilization of bio-waste, cost-effective, recyclable and biodegradable catalytic system, which provide good to excellent yields in a short reaction time.

Ashes from organic waste as reagents in synthetic chemistry: a review

Abstract: The decline of fossil- and ore-based materials is calling for more recycling of waste into new materials Here, I review the recycling of ashes from biomass into reagents for chemical synthesis and biodiesel production Biomass includes banana, pomegranate, rice, papaya, century plant, water hyacinth, bael fruit, nilgiri, mango, onion, muskmelon fruit, pomelo, lemon fruit, teak and tamarind Chemical reactions include Knoevenagel condensation, Suzuki–Miyaura cross-coupling, Sonogashira reaction, Dakin reaction, Henry reaction, Ullmann coupling, Pd-catalyzed homocoupling, aromatic bromination, hydroxylation of arylboronic acids, hydration of nitriles and azide–alkyne click reaction The synthesis of peptide bonds, disulfides, aminochromenes, carboxycoumarins, diazohydroxy esters, imidazopyridines, pyranopyrazoles, chalcones, flavones and bisenols is described

Green synthesis, antileishmanial activity evaluation, and in silico studies of new amino acid-coupled 1,2,4-triazoles

Abstract: Candidates of triazole-containing amino acid derivatives 5a−k were prepared under green chemistry conditions via multicomponent reaction using lemon juice as an acidic catalyst. All compounds were characterized by different spectral and elemental analyses. They were evaluated for their in vitro antileishmanial activity against miltefosine and amphotericin B deoxycholate as reference drugs. Compounds 5c, 5d, 5e and 5f showed superior potencies to miltefosine by 200 folds. These compounds are well tolerated by experimental animals orally up to 250 mg/kg and parenterally up to 100 mg/kg. Reverse docking approach against validated leishmanial targets pinpointed mitogen-activated protein kinase (MAPK) as a possible putative antileishmanial target. In addition, in silico predictions revealed that these compounds exhibited promising drug-likeness and pharmacokinetics profile.

Ash of pomegranate peels (APP): A bio-waste heterogeneous catalyst for sustainable synthesis of α,α′-bis(substituted benzylidine)cycloalkanones and 2-arylidene-1-tetralones

Abstract: α,α′-bis(substituted benzylidene)cycloalkanones were efficiently prepared from variously substituted aldehydes and cycloalkanones in water by using ash of pomegranate peels (APP) as a catalyst. The APP-catalyst was obtained from bio-waste by simple thermal treatment to dry peels of pomegranate fruit and formation of its active phase was confirmed by FT-IR, XRD, XRF, EDX, SEM, DSC-TGA and BET techniques. The analysis revealed that the present catalyst has basic sites which promote the synthesis of desired products. The main attractions of our protocol are utilization of highly abundant bio-waste-derived catalyst and good-to-excellent yield in shortest reaction time. This green protocol was further extended for structurally diverse 2-arylidene-1-tetralones by condensation of equimolar quantity of aromatic aldehydes and 1-tetralone at low temperature. The catalyst could be quantitatively recovered and reused effectively for five times.