Udo Hasler

TL;DR: In this paper, the authors present a set of guidelines for the selection and interpretation of methods for use by investigators who aim to examine macro-autophagy and related processes, as well as for reviewers who need to provide realistic and reasonable critiques of papers that are focused on these processes.

TL;DR: This is the first study that delineates induction and degradation mechanisms of AQP2 endogenously expressed by a renal collecting duct principal cell line and inhibition of proteasomal activity prevented synthesis of AVP-inducible AQP 2 mRNA and protein.

TL;DR: In agreement with these in vitro findings, spironolactone prevented NF-kappaB-induced transcriptional activation observed in cortical collecting ducts of salt-restricted rats and pharmacologic antagonism or knockdown of the mineralocorticoid receptor prevented aldosterone-induced NF- kappaB activity.

TL;DR: Enhanced activity of prosurvival NF-κB—at the onset of hypertonic challenge that depends on p38 kinase—and Akt-dependent formation of p65-TonEBP complexes that bind to elements of NF-σκB-responsive genes are demonstrated.

TL;DR: Investigation of the effect of increased extracellular tonicity/osmolarity on vasopressin-inducible aquaporin-2 (AQP2) expression in immortalized mouse collecting duct principal cells finds that on the long-term, vasopressingin (AVP) and hypertonicity increased AQP2 expression in a synergistic manner.