U
Ugo Orfanelli
Publications - 5
Citations - 2489
Ugo Orfanelli is an academic researcher. The author has contributed to research in topics: Biology & Chemistry. The author has an hindex of 1, co-authored 1 publications receiving 2345 citations.
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Isolation and Characterization of Tumorigenic, Stem-like Neural Precursors from Human Glioblastoma
Rossella Galli,Elena Binda,Ugo Orfanelli,Barbara Cipelletti,Angela Gritti,Simona De Vitis,Roberta Fiocco,Chiara Foroni,Francesco DiMeco,Angelo L. Vescovi +9 more
TL;DR: It is reported that, unlike other brain cancers, the lethal glioblastoma multiforme contains neural precursors endowed with all of the critical features expected from neural stem cells.
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Preclinical evidence of a direct pro-survival role of arginine deprivation in multiple myeloma
Matteo Trudu,Laura Oliva,Ugo Orfanelli,Alessandra Romano,Francesco Di Raimondo,Francesca Sanvito,Maurilio Ponzoni,Simone Cenci +7 more
TL;DR: A novel direct pro-survival effect of arginine deprivation on myeloma cells is revealed, with potential therapeutic implications, and the relevance of the identified circuit in vivo is challenged.
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P-109: ER-phagic control of lipid metabolism supports multiple myeloma cell survival
Laura Oliva,Matteo Trudu,Ugo Orfanelli,Tommaso Perini,Laura Cassina,Desirée Zambroni,Alessia Loffreda,Andrea Raimondi,Massimo Resnati,Alessandra Boletta,Simone Cenci +10 more
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Targeting the Mitochondrial Protease Clpp Unveils Mitochondrial Vulnerabilities in Multiple Myeloma
Tommaso Perini,Laura Oliva,M. Materozzi,Rossella Del Pizzo,Laura Cassina,Mehmet Kemal Samur,Ugo Orfanelli,Enric Milán,Alessandra Boletta,Nikhil C. Munshi,Simone Cenci +10 more
TL;DR: In this paper , the authors investigated the role of ClpP in mitochondrial and cellular homeostasis in multiple myeloma (MM) cells and tested it as a possible anti-myeloma target.