Author
Ulf Jansson
Other affiliations: Lund University, University of Gothenburg, Boston Children's Hospital
Bio: Ulf Jansson is an academic researcher from Stockholm University. The author has contributed to research in topics: Coeliac disease & Human geography. The author has an hindex of 13, co-authored 34 publications receiving 805 citations. Previous affiliations of Ulf Jansson include Lund University & University of Gothenburg.
Topics: Coeliac disease, Human geography, Gluten, Gliadin, Population
Papers
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University of Copenhagen1, Humboldt University of Berlin2, Leibniz Institute for Neurobiology3, Alpen-Adria-Universität Klagenfurt4, VU University Amsterdam5, Slovenian Academy of Sciences and Arts6, Ghent University7, Norwegian University of Science and Technology8, University of Eastern Finland9, Aix-Marseille University10, University of Edinburgh11, University of Luxembourg12, University of Malta13, Charles University in Prague14, Technical University of Madrid15, Slovak Academy of Sciences16, Stockholm University17, Jagiellonian University18, University of West Hungary19, University of Tartu20, University of Latvia21, Wageningen University and Research Centre22, Spanish National Research Council23, University of the Aegean24, University of Bucharest25, Potsdam Institute for Climate Impact Research26, University of Potsdam27, University of Tirana28
TL;DR: In this article, the authors examined the evolution of European land management over the past 200 years with the aim of identifying key episodes of changes in land management, and their underlying technological, institutional and economic drivers.
233 citations
01 Jan 2015
229 citations
TL;DR: Although the prevalence of coeliac disease was comparatively low in this study of Swedish children with short stature, it emphasizes the fact that coeliasis disease must be considered in a child with long stature even in the absence of gastrointestinal symptoms.
Abstract: Eighty-seven children with short stature (height more than 2 SD below the mean for age and sex) were investigated by small intestinal biopsy. There was no obvious reason for their growth retardation found by routine examination and they had no gastrointestinal symptoms. Coeliac disease was found in two children and probable coeliac disease in two children. Although the prevalence of coeliac disease was comparatively low in this study of Swedish children with short stature, it emphasizes the fact that coeliac disease must be considered in a child with short stature even in the absence of gastrointestinal symptoms.
59 citations
TL;DR: Down syndrome is associated with immune-related disorders such as hypothyroidism, insulin-dependent diabetes mellitus, and celiac disease, and antigliadin antibodies (AGA) in 54 patients with Down syndrome were determined.
Abstract: Down syndrome is associated with immune-related disorders such as hypothyroidism, insulin-dependent diabetes mellitus, and celiac disease. In this study we determined antigliadin antibodies (AGA) in 54 patients with Down syndrome; 22 had AGA values above the cutoff limit. Nineteen patients underwent intestinal biopsy, and total or subtotal villous atrophy was found in nine. There was a total of 65 patients with Down syndrome in our area of southern Sweden; two were already known to have celiac disease. The minimum prevalence of celiac disease in Down syndrome in this area in southern Sweden was 11 of 65 or 16.9%.
57 citations
TL;DR: Gene expression profiling shows promise as a diagnostic tool and for follow-up of CD, but further evaluation is needed.
Abstract: Celiac disease (CD) is identified by histopathologic changes in the small intestine which normalize during a gluten-free diet. The histopathologic assessment of duodenal biopsies is usually routine but can be difficult. This study investigated gene expression profiling as a diagnostic tool. A total of 109 genes were selected to reflect alterations in crypt-villi architecture, inflammatory response, and intestinal permeability and were examined for differential expression in normal mucosa compared with CD mucosa in pediatric patients. Biopsies were classified using discriminant analysis of gene expression. Fifty genes were differentially expressed, of which eight (APOC3, CYP3A4, OCLN, MAD2L1, MKI67, CXCL11, IL17A, and CTLA4) discriminated normal mucosa from CD mucosa without classification errors using leave-one-out cross-validation (n = 39) and identified the degree of mucosal damage. Validation using an independent set of biopsies (n = 27) resulted in four discrepant cases. Biopsies from two of these cases showed a patchy distribution of lesions, indicating that discriminant analysis based on single biopsies failed to identify CD mucosa. In the other two cases, serology support class according to discriminant analysis and histologic specimens were judged suboptimal but assessable. Gene expression profiling shows promise as a diagnostic tool and for follow-up of CD, but further evaluation is needed.
38 citations
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TL;DR: The current gold standard for the diagnosis of CD remains histologic confirmation of the intestinal damage in serologically positive individuals, and the keystone treatment of CD patients is a lifelong elimination diet in which food products containing gluten are avoided.
1,218 citations
TL;DR: This technical review addresses the state of evidence for celiac disease epidemiology, detection by serologic testing, diagnosis by biopsy, treatment, and outcome.
764 citations
TL;DR: The sensitivity of EMA and tTG tests appears to be lower than reported when milder histologic grades are used to define CD (below 90%).
505 citations
TL;DR: The ingestion of contaminating gluten should be kept lower than 50 mg/d in the treatment of CD, and no significant differences in the IEL count were found between the 3 groups.
474 citations
441 citations