U
Ulrich Zügel
Researcher at Bayer Schering Pharma AG
Publications - 42
Citations - 7401
Ulrich Zügel is an academic researcher from Bayer Schering Pharma AG. The author has contributed to research in topics: Calcitriol receptor & Immune system. The author has an hindex of 24, co-authored 42 publications receiving 6883 citations. Previous affiliations of Ulrich Zügel include University of Ulm & Schering AG.
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Journal ArticleDOI
Toll-Like Receptor Triggering of a Vitamin D-Mediated Human Antimicrobial Response
Philip T. Liu,Steffen Stenger,Huiying Li,Linda Wenzel,Belinda H. Tan,Stephan R. Krutzik,Maria Teresa Ochoa,Jürgen Schauber,Kent Wu,Christoph Meinken,Diane L. Kamen,Manfred Wagner,Robert Bals,Andreas Steinmeyer,Ulrich Zügel,Richard L. Gallo,David Eisenberg,Martin Hewison,Bruce W. Hollis,John S. Adams,Barry R. Bloom,Robert L. Modlin +21 more
TL;DR: The data support a link between TLRs and vitamin D–mediated innate immunity and suggest that differences in ability of human populations to produce vitamin D may contribute to susceptibility to microbial infection.
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Injury enhances TLR2 function and antimicrobial peptide expression through a vitamin D–dependent mechanism
Jürgen Schauber,Robert A. Dorschner,Robert A. Dorschner,Alvin B. Coda,Alvin B. Coda,Amanda S. Büchau,Amanda S. Büchau,Philip T. Liu,David Kiken,David Kiken,Yolanda R. Helfrich,Sewon Kang,Hashem Z Elalieh,Andreas Steinmeyer,Ulrich Zügel,Daniel D. Bikle,Robert L. Modlin,Richard L. Gallo,Richard L. Gallo +18 more
TL;DR: What is believed to be a previously unexpected role for vitamin D3 in innate immunity is demonstrated, enabling keratinocytes to recognize and respond to microbes and to protect wounds against infection.
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Role of Heat Shock Proteins in Protection from and Pathogenesis of Infectious Diseases
TL;DR: An overview of the role of hsp in immunity with a focus on infectious and autoimmune diseases is provided.
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Vitamin D Is Required for IFN-γ–Mediated Antimicrobial Activity of Human Macrophages
Mario Fabri,Steffen Stenger,Dong-Min Shin,Jae-Min Yuk,Philip T. Liu,Susan Realegeno,Hye-Mi Lee,Stephan R. Krutzik,Mirjam Schenk,Peter A. Sieling,Rosane M. B. Teles,Dennis Montoya,Shankar S. Iyer,Heiko Bruns,David M. Lewinsohn,Bruce W. Hollis,Martin Hewison,John S. Adams,Andreas Steinmeyer,Ulrich Zügel,Genhong Cheng,Eun-Kyeong Jo,Barry R. Bloom,Robert L. Modlin +23 more
TL;DR: The authors found that cells from the adaptive immune system—T cells—governed bacterial control by releasing the cytokine interferon-γ (IFN-γ), which then activated infected macrophages, inciting the cells to attack the invading M. tuberculosis.
Journal ArticleDOI
Convergence of IL-1β and VDR Activation Pathways in Human TLR2/1-Induced Antimicrobial Responses
Philip T. Liu,Mirjam Schenk,Valencia P. Walker,Paul W. Dempsey,Melissa Kanchanapoomi,Matthew Wheelwright,Aria Vazirnia,Xiaoran Zhang,Andreas Steinmeyer,Ulrich Zügel,Bruce W. Hollis,Genhong Cheng,Robert L. Modlin +12 more
TL;DR: A novel mechanism of host defense requiring the induction of IL-1β in synergy with vitamin D activation, for the TLR-induced antimicrobial pathway against an intracellular pathogen is identified.