U
Umut Eser
Researcher at Harvard University
Publications - 12
Citations - 740
Umut Eser is an academic researcher from Harvard University. The author has contributed to research in topics: Gene & Regulation of gene expression. The author has an hindex of 9, co-authored 12 publications receiving 630 citations. Previous affiliations of Umut Eser include Stanford University.
Papers
More filters
Journal ArticleDOI
Native elongating transcript sequencing reveals human transcriptional activity at nucleotide resolution.
Andreas Mayer,Julia di Iulio,Seth Maleri,Umut Eser,Jeff Vierstra,Alex Reynolds,Richard Sandstrom,John A. Stamatoyannopoulos,L. Stirling Churchman +8 more
TL;DR: A simple and powerful approach for performing native elongating transcript sequencing (NET-seq) in human cells that globally maps strand-specific Pol II density at nucleotide resolution and reveals stereotypic Pol II pausing coincident with transcription factor occupancy.
Journal ArticleDOI
Commitment to a cellular transition precedes genome-wide transcriptional change
TL;DR: It is found that genes within the G1/S regulon have a well-defined distribution of transcriptional activation times, which results in a logical OR function for gene expression and partially explains activation timing.
Journal ArticleDOI
An Algorithm to Automate Yeast Segmentation and Tracking
TL;DR: An algorithm is presented that accomplishes fully automated segmentation and tracking of budding yeast cells within growing colonies using prior information of yeast-specific traits to segment an image using a set of threshold values rather than one specific optimized threshold.
Journal ArticleDOI
Form and function of topologically associating genomic domains in budding yeast
Umut Eser,Devon Chandler-Brown,Ferhat Ay,Aaron F. Straight,Zhijun Duan,William Stafford Noble,Jan M. Skotheim +6 more
TL;DR: This work describes the existence of topologically associating domains in budding yeast and shows that these domains regulate replication timing so that origins within a domain fire synchronously, and identifies a molecular mechanism specifically regulating interactions between pericentric origins.
Journal ArticleDOI
The Ground State and Evolution of Promoter Region Directionality.
TL;DR: Strikingly, fortuitous promoter regions arising in foreign DNA produce equal transcription in both directions, indicating that divergent transcription is a mechanistic feature that does not imply a function for these transcripts.