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Ursula Straschil
Researcher at Imperial College London
Publications - 28
Citations - 1640
Ursula Straschil is an academic researcher from Imperial College London. The author has contributed to research in topics: Plasmodium falciparum & Plasmodium berghei. The author has an hindex of 18, co-authored 27 publications receiving 1338 citations. Previous affiliations of Ursula Straschil include University of Nottingham.
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Journal ArticleDOI
The systematic functional analysis of Plasmodium protein kinases identifies essential regulators of mosquito transmission
Rita Tewari,Ursula Straschil,Ursula Straschil,Alex Bateman,Ulrike Böhme,Inna Cherevach,Peng Gong,Arnab Pain,Arnab Pain,Oliver Billker,Oliver Billker +10 more
TL;DR: A systematic functional analysis of ePKs in the genetically tractable rodent parasite Plasmodium berghei found that 23 e PKs are redundant for asexual erythrocytic parasite development in mice and identifies functional clusters of kinases required for sexual development and sporogony.
Journal ArticleDOI
Male and Female Plasmodium falciparum Mature Gametocytes Show Different Responses to Antimalarial Drugs
Michael J. Delves,Andrea Ruecker,Ursula Straschil,Joël Lelièvre,Sara R. Marques,María José López-Barragán,Esperanza Herreros,Robert E. Sinden +7 more
TL;DR: These findings show firstly that the antimalarial responses of male and female gametocytes differ and secondly that the mature male gametocyte should be considered a more vulnerable target than the femalegametocyte for transmission-blocking drugs.
Journal ArticleDOI
A male and female gametocyte functional viability assay to identify biologically relevant malaria transmission-blocking drugs
Andrea Ruecker,Derrick K. Mathias,Ursula Straschil,Thomas S. Churcher,Rhoel R. Dinglasan,Didier Leroy,Robert E. Sinden,Michael J. Delves +7 more
TL;DR: The P. falciparum dual gamete formation assay (PfDGFA) is developed, which faithfully simulates the initial stages of the PfSMFA in vitro and accurately predicts activity in PfSMFAs, which validates and supports its adoption into the transmission-stage screening pipeline.
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Genome-wide Functional Analysis of Plasmodium Protein Phosphatases Reveals Key Regulators of Parasite Development and Differentiation
David S. Guttery,Benoit Poulin,Abhinay Ramaprasad,Richard J. Wall,David J. P. Ferguson,Declan Brady,Eva Maria Patzewitz,Sarah Whipple,Ursula Straschil,Megan H. Wright,Alyaa Mohamed,Anand Radhakrishnan,Stefan T. Arold,Edward W. Tate,Anthony A. Holder,Bill Wickstead,Arnab Pain,Rita Tewari +17 more
TL;DR: Systematic functional analyses of PPs in Plasmodium are provided to identify how phosphatases regulate parasite development and differentiation, and can inform the identification of drug targets for malaria.
Journal ArticleDOI
Routine in vitro culture of P. falciparum gametocytes to evaluate novel transmission-blocking interventions
Michael J. Delves,Ursula Straschil,Andrea Ruecker,Celia Miguel-Blanco,Sara R. Marques,Alexandre Dufour,Alexandre Dufour,Jake Baum,Robert E. Sinden +8 more
TL;DR: It is shown how functionally viable gametocytes can be used to evaluate transmission-blocking drugs both in a field setting and at high throughput (HTP) for drug discovery.