U
Ushio Kikkawa
Researcher at Kobe University
Publications - 133
Citations - 19865
Ushio Kikkawa is an academic researcher from Kobe University. The author has contributed to research in topics: Protein kinase C & Protein kinase A. The author has an hindex of 59, co-authored 129 publications receiving 19588 citations. Previous affiliations of Ushio Kikkawa include National Institute for Basic Biology, Japan.
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Direct activation of calcium-activated, phospholipid-dependent protein kinase by tumor-promoting phorbol esters
TL;DR: Kinetic analysis indicates that TPA can substitute for diacylglycerol and greatly increases the affinity of the enzyme for Ca2+ as well as for phospholipid, and various phorbol derivatives which have been shown to be active in tumor promotion are also capable of activating this protein kinase in in vitro systems.
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Activation of calcium and phospholipid-dependent protein kinase by diacylglycerol, its possible relation to phosphatidylinositol turnover.
TL;DR: A possible coupling is proposed between the protein kinase activation and phosphatidylinositol turnover which can be provoked by various extracellular messengers.
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Calcium-activated, phospholipid-dependent protein kinase from rat brain. Subcellular distribution, purification, and properties.
TL;DR: The subcellular distribution of Ca2+-activated, phospholipid-dependent protein kinase in rat brain was investigated and most of the enzyme was found to be associated with synaptosomal membranes, indistinguishable from the cytosol protein Kinase in physical, kinetic, and catalytic properties.
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Protein kinase C as a possible receptor protein of tumor-promoting phorbol esters.
TL;DR: It is suggestive that protein kinase C is a phorbol ester-receptive protein, and the results presented seem to provide clues for clarifying the mechanism of tumor promotion.