V
V. V. Kakkar
Publications - 46
Citations - 1113
V. V. Kakkar is an academic researcher. The author has contributed to research in topics: Protein C deficiency & Thrombin. The author has an hindex of 19, co-authored 46 publications receiving 1088 citations.
Papers
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Journal ArticleDOI
Factor VIII gene inversions in severe hemophilia A: results of an international consortium study
Stylianos E. Antonarakis,J. P. Rossiter,M. Young,J. Horst,P. De Moerloose,S. S. Sommer,Rhett P. Ketterling,H. H. Kazazian,Claude Negrier,Christine Vinciguerra,Jane Gitschier,Michel Goossens,E. Girodon,N. Ghanem,F. Plassa,Jean-Maurice Lavergne,M. Vidaud,J. M. Costa,Y. Laurian,S. W. Lin,S. R. Lin,M. C. Shen,David Lillicrap,Sherryl A. M. Taylor,S. Windsor,Sophie Valleix,K. Nafa,Y. Sultan,Marc Delpech,Cindy L. Vnencak-Jones,John A. Phillips,Rolf Ljung,E. Koumbarelis,A. Gialeraki,T. Mandalaki,P. V. Jenkins,Peter William Collins,K. J. Pasi,Anne Goodeve,Ian R. Peake,F. E. Preston,Marianne Schwartz,Elma Scheibel,Jørgen Ingerslev,David Neil Cooper,David Stuart Millar,V. V. Kakkar,F. Giannelli,J.A. Naylor,E. F. Tizzano,M. Baiget,M. Domenech,Carmen Altisent,J. Tusell,M. Beneyto,J. I. Lorenzo,Christine Gaucher,Claudine Mazurier,Kathelijne Peerlinck,Gert Matthijs,Jj. Cassiman,Jozef Vermylen,P. G. Mori,M. Acquila,D. Caprino,Hiroshi Inaba +65 more
TL;DR: The presence of factor VII inversions is not a major predisposing factor for the development of factor VIII inhibitors; however, slightly more patients with severe hemophilia A and factor VIII inversions develop inhibitors than patients without inversions.
Book
Mechanisms of Platelet Activation and Control
TL;DR: In 20 papers from an April 1992 symposium at the Thrombosis Research Institute in London, biochemists, pharmacologists, cell biologists, and clinicians synthesize the recent surge of new information about the molecular mechanism of platelet activity.
Journal Article
The proliferative responsiveness of human vascular smooth muscle cells to endothelin correlates with endothelin receptor density.
TL;DR: It is suggested that increased levels of ET receptors on HVSMC, as observed in atherosclerotic plaques, may predispose them to ET-stimulated proliferation.
Journal ArticleDOI
The relative molecular mass dependence of the anti-factor Xa properties of heparin.
TL;DR: Data suggest that the increased rates of inhibition observed with heparins of higher Mr may be due to an involvement of heparin binding to factor Xa as well as to antithrombin III.
Journal ArticleDOI
The molecular genetic analysis of haemophilia A; characterization of six partial deletions in the factor VIII gene.
David Stuart Millar,R. A. Steinbrecher,Kerstin Wieland,Catherine B. Grundy,U. Martinowitz,Michael Krawczak,Barbara Zoll,D. Whitmore,J. Stephenson,R. S. Mibashan,V. V. Kakkar,David Neil Cooper +11 more
TL;DR: In a survey of 528 unrelated haemophilia A patients, six partial deletions of the factor VIII (FVIII) gene were detected by Southern blotting and statistical analysis of currently available data did not provide any evidence for a deletion “hotspot”.