V. V. Mizintsev

Bio: V. V. Mizintsev is an academic researcher from Russian Academy of Sciences. The author has contributed to research in topics: Cyanation & Sodium. The author has an hindex of 2, co-authored 7 publications receiving 9 citations.

Stereochemistry of the remote oxidative cyanation of methylcyclohexanones

Abstract: 1. During the oxidative cyanation of 2-, 3-, and 4-methylcyclohexanones in the Na2S2O8-NaCN system the corresponding 4-cyano(methyl)cyclohexanones are formed regiospecifically. 2. The oxidative cyanation of 2- and 3-methylcyclohexanones takes place diastereoselectively with the formation of trans- and cis-4-cyano-2(3)-methylcyclohexanones in a ratio of 1.5∶1 (or 2∶1). The selectivity of cyanation is determined by the bridge structure of the intermediate 4-oxo(methyl)cyclohexyl radicals, which are the precursors of the 4-cyanocyclohexanones.

Remote oxidation of ketones to γ- and δ-diketones

Abstract: A single stage remote oxidation of ketones to γ- and δ-diketones has been carried out in a sodium peroxysulfate-iron(II) sulfate system.

One-step remote oxidative cyanation of ketones and aldehydes

Abstract: A one-step general synthesis has been developed for the synthesis of-γ-and δ-cyano-ketones and cyanoacids, based on the remote oxidative cyanation of carbonyl compounds by the sodium peroxydisulfate-sodium cyanide system.

Oxidative cyanation of aminyl radicals in sodium peroxydisulfate-sodium cyanide system

Abstract: 1. In a sodium peroxydisulfate-sodium cyanide system, the aminyl radicals RCH2CH2NH generated from n-alky1amines undergo N-cyanation to form alkylureas, and are oxidized to aldimines, predecessors of N-alkyl alkanamides and 2,5,6-trialkyl-1,3-diox-4-enes. 2. The introduction of sodium hydroxide to the oxidizing system favors the increase in the yield of alkylureas and alkyl cyanamides to 70%. 2-(Alkylamino)alkanonitriles are also formed. A simple method for separating the reaction products has been developed. 3. In the oxidation of sec-alkylamine, cyclohexylamine, oxidative deprotonation predominates over the N-cyanation reaction.

Compounds and methods for the treatment or prevention of flavivirus infections

Abstract: A compound is represented by Structural Formula (I), or a pharmaceutically acceptable salt thereof, wherein the variables of Structural Formula (I) are as described in the specification and the claims. A pharmaceutical composition comprises a compound represented by Structural Formula (I) or a pharmaceutically acceptable salt thereof, and a pharmaceutically acceptable carrier of excipient. A method of treating a HCV infection in a subject comprises administering to the subject a therapeutically effective amount of a compound represented by Structural Formula (I) or a pharmaceutically acceptable salt thereof. A method of inhibiting or reducing the activity of HCV polymerase in a subject or in a biological in vitro sample comprises administering to the subject or to the sample a therapeutically effective amount of a compound represented by Structural Formula (I) or a pharmaceutically acceptable salt thereof.

Thiophene analogues for the treatment or prevention of flavivirus infections

Abstract: The present invention relates to compounds represented by formula IA or pharmaceutically acceptable salts and solvates thereof which are useful for treating flaviviridae viral infections wherein R1 is C1-6 alkyl or C3-6 cycloalkyl; X is M is R5 is cyclohexyl which is unsubstituted or substituted one or more times by R13; R6 is or cyclohexyl which is substituted in the 4 position by R14; and Y, R14a and R14 are as defined herein.