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Author

V. V. Samoshin

Bio: V. V. Samoshin is an academic researcher from Russian Academy of Sciences. The author has contributed to research in topics: Triphenylamine & Iminium. The author has an hindex of 1, co-authored 2 publications receiving 4 citations.
Topics: Triphenylamine, Iminium, Cyanation, Superacid

Papers
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Journal ArticleDOI
TL;DR: In the Na2S2O8-NaCN system, the corresponding 4-cyano(methyl)cyclohexanones are formed regiospecifically.
Abstract: 1. During the oxidative cyanation of 2-, 3-, and 4-methylcyclohexanones in the Na2S2O8-NaCN system the corresponding 4-cyano(methyl)cyclohexanones are formed regiospecifically. 2. The oxidative cyanation of 2- and 3-methylcyclohexanones takes place diastereoselectively with the formation of trans- and cis-4-cyano-2(3)-methylcyclohexanones in a ratio of 1.5∶1 (or 2∶1). The selectivity of cyanation is determined by the bridge structure of the intermediate 4-oxo(methyl)cyclohexyl radicals, which are the precursors of the 4-cyanocyclohexanones.

3 citations

Journal ArticleDOI
TL;DR: The reaction of the 3∶1 molar ratio of the reagents HGeCl3 and triphenylamine at 20°C in benzene leads to the formation of a high yield of the iminium salt.
Abstract: 1. The reaction of the 3∶1 molar ratio of the reagents HGeCl3 and triphenylamine at 20°C in benzene leads to the formation of a high yield of the iminium salt — cis-3,5-bis (trichlorogermyl)cyclohexylidenediphenyliminium trichlorogermanate, whereby the transisomer is initially formed in the course of the reaction; the trans-isomer of the iminium salt isomerizes spontaneously to the cis-isomer. 2. The reaction of the 4∶1, and greater, molar ratio of the reagents HGeCl3 and triphenylamine at 80°C leads to the formal hydrogenation of the initially formed iminium salt with the formation of 3,5-bis(trichlorogermyl)cyclohexyldiphenylammonium trichlorogermanate.

1 citations


Cited by
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Patent
15 May 2006
TL;DR: In this paper, a method of treating a HCV infection in a subject comprises administering to the subject a therapeutically effective amount of a compound represented by Structural Formula (I) or a pharmaceutically acceptable salt thereof.
Abstract: A compound is represented by Structural Formula (I), or a pharmaceutically acceptable salt thereof, wherein the variables of Structural Formula (I) are as described in the specification and the claims. A pharmaceutical composition comprises a compound represented by Structural Formula (I) or a pharmaceutically acceptable salt thereof, and a pharmaceutically acceptable carrier of excipient. A method of treating a HCV infection in a subject comprises administering to the subject a therapeutically effective amount of a compound represented by Structural Formula (I) or a pharmaceutically acceptable salt thereof. A method of inhibiting or reducing the activity of HCV polymerase in a subject or in a biological in vitro sample comprises administering to the subject or to the sample a therapeutically effective amount of a compound represented by Structural Formula (I) or a pharmaceutically acceptable salt thereof.

101 citations

Patent
15 Nov 2007
TL;DR: The present invention relates to compounds represented by formula IA or pharmaceutically acceptable salts and solvates thereof which are useful for treating flaviviridae viral infections as discussed by the authors.
Abstract: The present invention relates to compounds represented by formula IA or pharmaceutically acceptable salts and solvates thereof which are useful for treating flaviviridae viral infections wherein R1 is C1-6 alkyl or C3-6 cycloalkyl; X is M is R5 is cyclohexyl which is unsubstituted or substituted one or more times by R13; R6 is or cyclohexyl which is substituted in the 4 position by R14; and Y, R14a and R14 are as defined herein.

21 citations

Journal ArticleDOI
TL;DR: In this article, a homolytic cycloaddition of dithiols 1,2 derived from trans- and eis-1,2-cyclohexanediols to alkynes, induced by Pr3B-O2, offers an extremely simple approach to trans and cis cyclohexano-fused 12-membered crown thialactones 4a-c-7a c.

21 citations

Reference EntryDOI
TL;DR: In this paper, the authors present synthesis, structure and physical properties of trichlorogermane and investigate the properties of HGeCl3 and GeCl4 with organic halides.
Abstract: 1 Introduction 2 Synthesis, Structure and Physical Properties of Trichlorogermane 3 Acidic and Superacidic Properties of Trichlorogermane 4 Electrochemical Investigation of HGeCl3 and GeCl4 5 Reactions of Trichlorogermane with Organic Halides 6 Reactions of Trichlorogermane with Unsaturated Compounds 7 Double Germylation 8 Reactions of HGeCl3 with Aromatic Compounds 9 Conclusions Keywords: trichlorogermane - acidic and superacidic properties; trichlorogermane - new superacid in organic chemistry; etherates of trichlorogermane; reactions of trichlorogermane with organic halides; trichlorogermane with unsaturated compounds; acidic properties of covalent trichlorogermane; reactions with conjugated dienes; reaction with anisole