V
V. Valsecchi
Publications - 3
Citations - 240
V. Valsecchi is an academic researcher. The author has contributed to research in topics: Gene & Proto-oncogene tyrosine-protein kinase Src. The author has an hindex of 3, co-authored 3 publications receiving 237 citations.
Papers
More filters
Journal ArticleDOI
Gene expression profiles of epithelial cells microscopically isolated from a breast-invasive ductal carcinoma and a nodal metastasis
Ileana Zucchi,E. Mento,Vladimir A. Kuznetsov,Maddalena Scotti,V. Valsecchi,Barbara Simionati,E. Vicinanza,Giorgio Valle,S. Pilotti,Rolland Reinbold,Paolo Vezzoni,Alberto Albertini,Renato Dulbecco +12 more
TL;DR: It is shown that the expression profiles obtained are exclusive of carcinoma cells with no contribution of non-epithelial cells, suggesting that the down-regulation of a set of genes may be the basic mechanism of cancer formation, while the up-regulation may characterize and possibly control the state of evolution of individual cancers.
Journal ArticleDOI
The properties of a mammary gland cancer stem cell
Ileana Zucchi,S. Sanzone,Simonetta Astigiano,Paride Pelucchi,Maddalena Scotti,V. Valsecchi,Ottavia Barbieri,Gloria Bertoli,Alberto Albertini,Rolland Reinbold,Renato Dulbecco +10 more
TL;DR: The properties of self-renewal, extensive capacity for proliferation, multilineage differentiation potential, and single-cell tumor-initiation potential suggest that LA7 cells are cancer stem cells and can be used as a model system to study the dynamics of tumor formation at the single- cell level.
Journal ArticleDOI
Association of rat8 with Fyn protein kinase via lipid rafts is required for rat mammary cell differentiation in vitro
Ileana Zucchi,Alessandro Prinetti,Maddalena Scotti,V. Valsecchi,Rea Valaperta,E. Mento,Rolland Reinbold,Paolo Vezzoni,Sandro Sonnino,Alberto Albertini,Renato Dulbecco +10 more
TL;DR: Results suggest that rat8, like fragilis, may be involved in developmental decisions and the demarcation of a subset of cells in the mammary gland that cause epithelial cells to develop into a network of tubuloalveolar structures involved in secretion.