Author
V Vats
Bio: V Vats is an academic researcher from All India Institute of Medical Sciences. The author has contributed to research in topics: Glucokinase & Glycogen. The author has an hindex of 12, co-authored 12 publications receiving 2692 citations.
Topics: Glucokinase, Glycogen, Alloxan, Fructose, Insulin resistance
Papers
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TL;DR: 45 plants and their products that have been mentioned/used in the Indian traditional system of medicine and have shown experimental or clinical anti-diabetic activity are reviewed.
1,641 citations
TL;DR: The aqueous extract of the bark of Pterocarpus marsupium and alcoholic extract of seeds of Trigonella foenum-graecum and leaves of Ocimum sanctum was investigated in both normal and alloxan-induced diabetic rats and showed a favorable effect on glucose disposition in glucose fed hyperglycemic rats.
294 citations
TL;DR: Assessment of the effect of OS on three important enzymes of carbohydrate metabolism in insulin-dependent (skeletal muscle and liver) and insulin-independent tissues (kidneys and brain) in STZ induced model of diabetes for 30 days found OS significantly decreased renal and two-kidney weight but not liver weight, and did not affect glycogen content in any tissue.
249 citations
TL;DR: Feeding of diet containing various doses of curry leaves to normal rats for 7 days as well as mild diabetic and moderate diabetic rats for 5 weeks showed varying hypoglycemic and anti-hyperglycemic effect.
146 citations
TL;DR: FG (1g/kg PO) was assessed for its effect on glycogen levels of insulin dependent (skeletal muscle and liver), insulin independent tissues (kidneys and brain) and enzymes such as glucokinase (GK), hexokinases (HK, and phosphofructokinase) and enzyme activity in diabetic controls and controls.
127 citations
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TL;DR: An overview of the classes of molecules present in plants is provided and some examples of the types of molecules and secondary metabolites that have led to the development of these pharmacologically active extracts are given.
1,899 citations
TL;DR: 45 plants and their products that have been mentioned/used in the Indian traditional system of medicine and have shown experimental or clinical anti-diabetic activity are reviewed.
1,641 citations
TL;DR: 86 natural medicines with regards to their origin, anti-diabetic active principles and/or pharmacological test results, which are commonly used in the traditional Chinese medical system and have demonstrated experimental or/and clinical anti-Diabetic effectiveness are reviewed.
900 citations
TL;DR: This review focuses on Indian Herbal drugs and plants used in the treatment of diabetes, especially in India, and a list of medicinal plants with proven antidiabetic and related beneficial effects and of herbal drugs used in treatment of Diabetes is compiled.
Abstract: Traditional Medicines derived from medicinal plants are used by about 60% of the world's population. This review focuses on Indian Herbal drugs and plants used in the treatment of diabetes, especially in India. Diabetes is an important human ailment afflicting many from various walks of life in different countries. In India it is proving to be a major health problem, especially in the urban areas. Though there are various approaches to reduce the ill effects of diabetes and its secondary complications, herbal formulations are preferred due to lesser side effects and low cost. A list of medicinal plants with proven antidiabetic and related beneficial effects and of herbal drugs used in treatment of diabetes is compiled. These include, Allium sativum, Eugenia jambolana, Momordica charantia Ocimum sanctum, Phyllanthus amarus, Pterocarpus marsupium, Tinospora cordifolia, Trigonella foenum graecum and Withania somnifera. One of the etiologic factors implicated in the development of diabetes and its complications is the damage induced by free radicals and hence an antidiabetic compound with antioxidant properties would be more beneficial. Therefore information on antioxidant effects of these medicinal plants is also included.
819 citations
TL;DR: Evaluated studies indicate that long term use of aspirin and similar agents, also called non-steroidal anti-inflammatory drugs (NSAIDs), can decrease the incidence of certain malignancies, including colorectal, oesophageal, breast, lung, and bladder cancers.
Abstract: Chemoprevention has been considered as a possible approach for cancer prevention. A significant effort has been made in the development of novel drugs for both cancer prevention and treatment over the past decade. Recent epidemiological studies and clinical trials indicate that long term use of aspirin and similar agents, also called non-steroidal anti-inflammatory drugs (NSAIDs), can decrease the incidence of certain malignancies, including colorectal, oesophageal, breast, lung, and bladder cancers. The best known targets of NSAIDs are cyclooxygenase (COX) enzymes, which convert arachidonic acid to prostaglandins (PGs) and thromboxane. COX-2 derived prostaglandin E(2)(PGE(2)) can promote tumour growth by binding its receptors and activating signalling pathways which control cell proliferation, migration, apoptosis, and/or angiogenesis. However, the prolonged use of high dosages of COX-2 selective inhibitors (COXIBs) is associated with unacceptable cardiovascular side effects. Thus it is crucial to develop more effective chemopreventive agents with minimal toxicity. Recent efforts to identify the molecular mechanisms by which PGE(2) promotes tumour growth and metastasis may provide opportunities for the development of safer strategies for cancer prevention and treatment.
796 citations