scispace - formally typeset
Search or ask a question
Author

Vahideh Zadsirjan

Bio: Vahideh Zadsirjan is an academic researcher from Alzahra University. The author has contributed to research in topics: Total synthesis & Catalysis. The author has an hindex of 22, co-authored 101 publications receiving 1696 citations.

Papers published on a yearly basis

Papers
More filters
Journal ArticleDOI
TL;DR: A comprehensive overview of top prescribed drugs containing nitrogen heterocycles, describing their pharmacological properties, medical applications and their selected synthetic pathways is presented in this paper, where the reported examples are actually limited to current top selling drugs and their synthetic information has been extracted from both scientific journals and the wider patent literature.
Abstract: Heteroatoms as well as heterocyclic scaffolds are frequently present as the common cores in a plethora of active pharmaceuticals natural products. Statistically, more than 85% of all biologically active compounds are heterocycles or comprise a heterocycle and most frequently, nitrogen heterocycles as a backbone in their complex structures. These facts disclose and emphasize the vital role of heterocycles in modern drug design and drug discovery. In this review, we try to present a comprehensive overview of top prescribed drugs containing nitrogen heterocycles, describing their pharmacological properties, medical applications and their selected synthetic pathways. It is worth mentioning that the reported examples are actually limited to current top selling drugs, being or containing N-heterocycles and their synthetic information has been extracted from both scientific journals and the wider patent literature.

271 citations

Journal ArticleDOI
TL;DR: In this article, the Buchwald-Hartwig amination reaction has attracted much attention in recent years, especially applied for construction of various heterocyclic systems, and the applications of this name reaction as an important C-N cross-coupling reaction applied to the total synthesis of natural products.

165 citations

Journal ArticleDOI
TL;DR: A simple, clean and environmentally benign route to the synthesis of 2-amino-4H-chromenes is described using Preyssler type heteropolyacid, H(14)[NaP(5)W(30)O(110)], as a green and reusable catalyst in water.

144 citations

Journal ArticleDOI
TL;DR: In this paper, the utility and versatility of oxazolidinones (Evans chiral auxiliaries) in the asymmetric aldol condensations for the total synthesis of natural products and complex targets are discussed.
Abstract: Asymmetric aldol reactions of oxazolidinones as chiral auxiliaries have been achieved and attracted significant consideration as one of the most powerful synthetic tools for the carbon–carbon bond-forming reactions. The methodology has been highly successful in the stereoselective construction of a number of natural products, antibiotics, and other medicinally important compounds. The present review is focused on the utility and versatility of oxazolidinones (Evans chiral auxiliaries) in the asymmetric aldol condensations for the total synthesis of natural products and complex targets.

133 citations

Journal ArticleDOI
TL;DR: This review aims to highlight the origins, structures, biological potencies, and synthetic approaches of those natural products bearing at least one benzofuran in their complex structures and especially focus on the step in which this key heterocycle is installed during the total synthesis of a natural product as the desired target.
Abstract: Research on natural products containing benzofuran has remarkably increased during the past few decades. Newly isolated natural products with complex structures are being studied, characterized and screened for possible biological activities. Several of such compounds have exhibited various biological activities, thus their total syntheses have attracted much attention from synthetic organic chemists. In this review, we aim to highlight the origins, structures, biological potencies, and synthetic approaches of those natural products bearing at least one benzofuran in their complex structures. Furthermore, we especially focus on the step in which this key heterocycle is installed during the total synthesis of a natural product as the desired target.

111 citations


Cited by
More filters
01 Jun 2005

3,154 citations

Journal ArticleDOI
01 Jan 1958-Nature
TL;DR: In this paper, the authors present an overview of the relationship between organic chemistry and natural products, focusing on the Stereochemistry and the Chemistry of Natural Products (SCHP).
Abstract: Organic Chemistry By Dr. I. L. Finar. Vol. 2: Stereochemistry and the Chemistry of Natural Products. Pp. xi + 733. (London and New York: Longmans, Green and Co., Ltd., 1956.) 40s. net.

1,037 citations