V
Valbona Luga
Researcher at University of Toronto
Publications - 10
Citations - 2581
Valbona Luga is an academic researcher from University of Toronto. The author has contributed to research in topics: Wnt signaling pathway & Microvesicles. The author has an hindex of 7, co-authored 8 publications receiving 2326 citations. Previous affiliations of Valbona Luga include Mount Sinai Hospital & Lunenfeld-Tanenbaum Research Institute.
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Journal ArticleDOI
Exosomes Mediate Stromal Mobilization of Autocrine Wnt-PCP Signaling in Breast Cancer Cell Migration
Valbona Luga,Liang Zhang,Alicia Viloria-Petit,Abiodun A. Ogunjimi,Mohammad R. Inanlou,Elaine Chiu,Marguerite Buchanan,Abdel Nasser Hosein,Mark Basik,Jeffrey L. Wrana,Jeffrey L. Wrana +10 more
TL;DR: It is reported that fibroblast-secreted exosomes promote breast cancer cell (BCC) protrusive activity and motility via Wnt-planar cell polarity (PCP) signaling and it is demonstrated that exosome-stimulated BCC protrusions display mutually exclusive localization of the core PCP complexes.
Journal ArticleDOI
High-throughput mapping of a dynamic signaling network in mammalian cells.
Miriam Barrios-Rodiles,Kevin R. Brown,Barish Ozdamar,Barish Ozdamar,Rohit Bose,Rohit Bose,Zhong Liu,Rob Donovan,Fukiko Shinjo,Yongmei Liu,Joanna Dembowy,Joanna Dembowy,Ian W. Taylor,Ian W. Taylor,Valbona Luga,Valbona Luga,Natasa Przulj,Mark D. Robinson,Harukazu Suzuki,Yoshihide Hayashizaki,Igor Jurisica,Igor Jurisica,Jeffrey L. Wrana,Jeffrey L. Wrana +23 more
TL;DR: LUMIER (for luminescence-based mammalian interactome mapping), an automated high-throughput technology, is developed and applied to the transforming growth factor–β (TGFβ) pathway and it is shown that Occludin regulates TGFβ type I receptor localization for efficient TGF β-dependent dissolution of tight junctions during epithelial-to-mesenchymal transitions.
Journal ArticleDOI
Regulation of Planar Cell Polarity by Smurf Ubiquitin Ligases
Masahiro Narimatsu,Rohit Bose,Rohit Bose,Melanie Pye,Liang Zhang,Bryan W. Miller,Peter Ching,Rui Sakuma,Valbona Luga,Valbona Luga,Luba Roncari,Liliana Attisano,Jeffrey L. Wrana,Jeffrey L. Wrana +13 more
TL;DR: It is shown that Smurfs engage in a noncanonical Wnt signaling pathway that targets the core PCP protein Prickle1 for ubiquitin-mediated degradation.
Journal ArticleDOI
Loss of the Timp gene family is sufficient for the acquisition of the CAF-like cell state
Masayuki Shimoda,Simona Principe,Hartland W. Jackson,Valbona Luga,Hui Fang,Sam D. Molyneux,Yang W. Shao,Alison Aiken,Paul Waterhouse,Christina Karamboulas,Franz M. Hess,Takashi Ohtsuka,Yasunori Okada,Laurie Ailles,Andreas Ludwig,Jeffrey L. Wrana,Thomas Kislinger,Rama Khokha +17 more
TL;DR: Generating quadruple TIMP knockout (TIMPless) fibroblasts is generated to unleash metalloproteinase activity within the tumour-stromal compartment and it is shown that complete Timp loss is sufficient for the acquisition of hallmark CAF functions.
Journal ArticleDOI
Tumor–Stroma Interaction: Revealing Fibroblast-Secreted Exosomes as Potent Regulators of Wnt-Planar Cell Polarity Signaling in Cancer Metastasis
Valbona Luga,Jeffrey L. Wrana +1 more
TL;DR: It is revealed that fibroblasts secrete exosomes that promote breast cancer cell (BCC) protrusive activity, motility, and metastasis by activating autocrine Wnt-PCP signaling in BCCs, and it is shown that Wnt ligands produced by BCCs tether to fibroblast exosome upon trafficking of exosomal ligands within BCCs.