V
Valerie I. Brown
Researcher at Boston Children's Hospital
Publications - 74
Citations - 2135
Valerie I. Brown is an academic researcher from Boston Children's Hospital. The author has contributed to research in topics: Transplantation & Medicine. The author has an hindex of 19, co-authored 59 publications receiving 1864 citations. Previous affiliations of Valerie I. Brown include Children's Hospital of Philadelphia & Penn State Milton S. Hershey Medical Center.
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Journal ArticleDOI
Synergistic interaction of p185c-neu and the EGF receptor leads to transformation of rodent fibroblasts
Yasuo Kokai,Jeffrey N. Myers,Takuro Wada,Valerie I. Brown,Charles LeVea,James G. Davis,Kunio Dobashi,Mark I. Greene +7 more
TL;DR: Observations demonstrate that two distinct, overexpressed tyrosine kinases can act synergistically to transform NIH 3T3 cells, thus identifying a novel mechanism that can lead to transformation.
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Dasatinib plus intensive chemotherapy in children, adolescents, and young adults with philadelphia chromosome–positive acute lymphoblastic leukemia: Results of children’s oncology group trial AALL0622
William B. Slayton,Kirk R. Schultz,John A. Kairalla,Meenakshi Devidas,Xinlei Mi,Michael A. Pulsipher,Bill H. Chang,Charles G. Mullighan,Ilaria Iacobucci,Lewis B. Silverman,Michael J. Borowitz,Andrew J. Carroll,Nyla A. Heerema,Julie M. Gastier-Foster,Brent L. Wood,Sherri L. Mizrahy,Thomas E. Merchant,Valerie I. Brown,Lance Sieger,Marilyn J. Siegel,Elizabeth A. Raetz,Naomi J. Winick,Mignon L. Loh,William L. Carroll,Stephen P. Hunger +24 more
TL;DR: Dasatinib was well tolerated with chemotherapy and provided outcomes similar to those with imatinib in COG AALL0031, where all patients received cranial irradiation.
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The mTOR inhibitor CCI-779 induces apoptosis and inhibits growth in preclinical models of primary adult human ALL
David T. Teachey,Dana A. Obzut,Dana A. Obzut,Dana A. Obzut,Jonathan Cooperman,Jonathan Cooperman,Jonathan Cooperman,Junjie Fang,Junjie Fang,Junjie Fang,Martin Carroll,Martin Carroll,Martin Carroll,John K. Choi,John K. Choi,John K. Choi,Peter J. Houghton,Peter J. Houghton,Peter J. Houghton,Valerie I. Brown,Valerie I. Brown,Valerie I. Brown,Stephan A. Grupp,Stephan A. Grupp,Stephan A. Grupp +24 more
TL;DR: It is concluded that MTIs can inhibit the growth of adult human ALL and deserve close examination as therapeutic agents against a disease that is often not curable with current therapy.
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Rapamycin is active against B-precursor leukemia in vitro and in vivo, an effect that is modulated by IL-7-mediated signaling.
Valerie I. Brown,Junjie Fang,Keith Alcorn,Rosalind Barr,Jenny M. Kim,Robert Wasserman,Stephan A. Grupp +6 more
TL;DR: It is found that rapamycin inhibited growth of B-precursor acute lymphoblastic leukemia lines in vitro, with evidence of apoptotic cell death, and that one of the growth signals inhibited by this class of drugs in precursor B leukemic cells may be IL-7-mediated.
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Mammalian target of rapamycin inhibitors and their potential role in therapy in leukaemia and other haematological malignancies
TL;DR: The rationale for using mTOR inhibitors in a variety of haematological diseases with a focus on their use in leukaemia is described.