V
Vamsi K. Mootha
Researcher at Broad Institute
Publications - 243
Citations - 90559
Vamsi K. Mootha is an academic researcher from Broad Institute. The author has contributed to research in topics: Mitochondrion & Mitochondrial DNA. The author has an hindex of 85, co-authored 227 publications receiving 73860 citations. Previous affiliations of Vamsi K. Mootha include Harvard University & Beth Israel Deaconess Medical Center.
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Journal ArticleDOI
Abnormal glucose homeostasis in skeletal muscle–specific PGC-1α knockout mice reveals skeletal muscle–pancreatic β cell crosstalk
Christoph Handschin,Cheol Soo Choi,Sherry Chin,Sheene Kim,Dan Kawamori,Amarnath J. Kurpad,Nicole Neubauer,Jiang Hu,Vamsi K. Mootha,Vamsi K. Mootha,Young-Bum Kim,Rohit N. Kulkarni,Gerald I. Shulman,Bruce M. Spiegelman +13 more
TL;DR: A causal role for muscle PGC-1alpha in maintenance of glucose homeostasis is illustrated and an unexpected cytokine-mediated crosstalk between skeletal muscle and pancreatic islets is highlighted.
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TRPV4 is a regulator of adipose oxidative metabolism, inflammation and energy homeostasis
Li Ye,Sandra Kleiner,Jun Wu,Rajan Sah,Rana K. Gupta,Alexander S. Banks,Paul Cohen,Melin J. Khandekar,Pontus Boström,Rina J. Mepani,Dina Laznik,Theodore M. Kamenecka,Xinyi Song,Wolfgang Liedtke,Vamsi K. Mootha,Pere Puigserver,Patrick R. Griffin,David E. Clapham,Bruce M. Spiegelman +18 more
TL;DR: The role of TRPV4 as a cell-autonomous mediator for both the thermogenic and proinflammatory programs in adipocytes could offer a target for treating obesity and related metabolic diseases.
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A bacterial cytidine deaminase toxin enables CRISPR-free mitochondrial base editing.
Beverly Mok,Beverly Mok,Beverly Mok,Marcos H. de Moraes,Jun Zeng,Dustin E Bosch,Anna V. Kotrys,Anna V. Kotrys,Anna V. Kotrys,Aditya Raguram,Aditya Raguram,Aditya Raguram,FoSheng Hsu,Matthew C. Radey,S. Brook Peterson,Vamsi K. Mootha,Vamsi K. Mootha,Joseph D. Mougous,David R. Liu,David R. Liu,David R. Liu +20 more
TL;DR: An interbacterial toxin that catalyses the deamination of cytidines within double-stranded DNA forms part of a CRISPR-free, RNA-free base editing system that enables manipulation of human mitochondrial DNA.
Journal ArticleDOI
Nutrient-sensitized screening for drugs that shift energy metabolism from mitochondrial respiration to glycolysis
Vishal M. Gohil,Sunil A Sheth,Sunil A Sheth,Roland Nilsson,Roland Nilsson,Andrew P. Wojtovich,Jeong Hyun Lee,Fabiana Perocchi,Fabiana Perocchi,William W. Chen,William W. Chen,Clary B. Clish,Cenk Ayata,Paul S. Brookes,Vamsi K. Mootha,Vamsi K. Mootha +15 more
TL;DR: The antiemetic meclizine pretreatment confers cardioprotection and neuroprotection against ischemia-reperfusion injury in murine models andNutrient-sensitized screening may provide a useful framework for understanding gene function and drug action within the context of energy metabolism.
Directed evolution of APEX2 for electron microscopy and proximity labeling
Kimberli J. Kamer,Thomas J. Deerinck,Mark H. Ellisman,Vamsi K. Mootha,Stephanie S Lam,Jeffrey D. Martell,Alice Y. Ting +6 more
TL;DR: The authors' evolved APEX2 is far more active in cells, enabling the superior enrichment of endogenous mitochondrial and endoplasmic reticulum membrane proteins and the use of electron microscopy to resolve the sub-mitochondrial localization of calcium uptake regulatory protein MICU1.