V
Vamsi K. Mootha
Researcher at Broad Institute
Publications - 243
Citations - 90559
Vamsi K. Mootha is an academic researcher from Broad Institute. The author has contributed to research in topics: Mitochondrion & Mitochondrial DNA. The author has an hindex of 85, co-authored 227 publications receiving 73860 citations. Previous affiliations of Vamsi K. Mootha include Harvard University & Beth Israel Deaconess Medical Center.
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Journal ArticleDOI
A plasma signature of human mitochondrial disease revealed through metabolic profiling of spent media from cultured muscle cells
Oded Shaham,Nancy G. Slate,Olga Goldberger,Qiuwei Xu,Arvind Ramanathan,Amanda Souza,Clary B. Clish,Katherine B. Sims,Vamsi K. Mootha +8 more
TL;DR: This study identifies plasma creatine as a potential biomarker of human mitochondrial dysfunction that could be clinically useful and illustrates how spent media from cellular models of disease may provide a window into the biochemical derangements in human plasma.
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IGF2BP2/IMP2 Deficient Mice Resist Obesity through enhanced translation of Ucp1 mRNA and other mRNAs encoding Mitochondrial Proteins
Ning Dai,Liping Zhao,Diedra M. Wrighting,Diedra M. Wrighting,Dana Kramer,Amit R. Majithia,Yanqun Wang,Valentin Cracan,Diego Borges-Rivera,Diego Borges-Rivera,Vamsi K. Mootha,Matthias Nahrendorf,David R. Thorburn,David R. Thorburn,Liliana Minichiello,David Altshuler,Joseph Avruch +16 more
TL;DR: IMP2 limits longevity and regulates nutrient and energy metabolism in the mouse by controlling the translation of its client mRNAs.
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The homeobox protein Prox1 is a negative modulator of ERRα/PGC-1α bioenergetic functions
Alexis Charest-Marcotte,Catherine R. Dufour,Brian J. Wilson,Annie M. Tremblay,Lillian J. Eichner,Daniel H. Arlow,Vamsi K. Mootha,Vincent Giguère +7 more
TL;DR: DNA motif analysis suggests that Prox1 interacts with the genome through tethering to ERRalpha and other factors, revealing an unexpected role for ProX1 in the control of energy homeostasis.
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Cryo-EM structure of a fungal mitochondrial calcium uniporter
Nam X. Nguyen,Jean Paul Armache,Changkeun Lee,Changkeun Lee,Yi Yang,Weizhong Zeng,Vamsi K. Mootha,Yifan Cheng,Xiao Chen Bai,Youxing Jiang +9 more
TL;DR: A cryo-electron microscopy structure of fungal mitochondrial calcium uniporter shows that the channel is tetrameric and sheds light on channel assembly and function, and offers insights into channel assembly, selective calcium permeation, and inhibitor binding.
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Titration of mitochondrial fusion rescues Mff-deficient cardiomyopathy
Hsiuchen Chen,Shuxun Ren,Clary B. Clish,Mohit Jain,Vamsi K. Mootha,Vamsi K. Mootha,J. Michael McCaffery,David C. Chan +7 more
TL;DR: Mice deficient for mitochondrial fission factor die from severe cardiomyopathy, but cardiac function, tissue integrity, and mitochondrial respiration are robustly rescued by rebalancing mitochondrial dynamics through deletion of Mitofusin 1 (Mfn1).