V
Vamsi K. Mootha
Researcher at Broad Institute
Publications - 243
Citations - 90559
Vamsi K. Mootha is an academic researcher from Broad Institute. The author has contributed to research in topics: Mitochondrion & Mitochondrial DNA. The author has an hindex of 85, co-authored 227 publications receiving 73860 citations. Previous affiliations of Vamsi K. Mootha include Harvard University & Beth Israel Deaconess Medical Center.
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Journal ArticleDOI
Genetic Screen for Cell Fitness in High or Low Oxygen Highlights Mitochondrial and Lipid Metabolism.
Isha H. Jain,Isha H. Jain,Sarah E. Calvo,Sarah E. Calvo,Andrew L. Markhard,Andrew L. Markhard,Owen S. Skinner,Owen S. Skinner,Tsz-Leung To,Tsz-Leung To,Tslil Ast,Tslil Ast,Vamsi K. Mootha,Vamsi K. Mootha +13 more
TL;DR: This resource performs genome-wide CRISPR growth screens at 21%, 5%, and 1% oxygen to systematically identify gene knockouts with relative fitness defects in high oxygen or low oxygen, and links hundreds of genes to oxygen homeostasis.
Journal ArticleDOI
Hypoxia treatment reverses neurodegenerative disease in a mouse model of Leigh syndrome
Michele Ferrari,Isha H. Jain,Olga Goldberger,Olga Goldberger,Emanuele Rezoagli,Robrecht Thoonen,Kai-Hung Cheng,David E. Sosnovik,Marielle Scherrer-Crosbie,Vamsi K. Mootha,Warren M. Zapol +10 more
TL;DR: It is shown that breathing normobaric 11% O2 in mice with late-stage encephalopathy reverses their established neurological disease, evidenced by improved behavior, circulating disease biomarkers, and survival rates.
Journal ArticleDOI
Antibodies to biotin enable large-scale detection of biotinylation sites on proteins
Namrata D. Udeshi,Kayvon Pedram,Tanya Svinkina,Shaunt Fereshetian,Samuel A. Myers,Ozan Aygün,Karsten Krug,Karl R. Clauser,Dominic Ryan,Tslil Ast,Tslil Ast,Vamsi K. Mootha,Vamsi K. Mootha,Alice Y. Ting,Steven A. Carr +14 more
TL;DR: It is shown that anti-biotin antibodies enable unprecedented enrichment of biotinylated peptides from complex peptide mixtures.
Journal ArticleDOI
Mutations in LYRM4, encoding iron-sulfur cluster biogenesis factor ISD11, cause deficiency of multiple respiratory chain complexes
Sze Chern Lim,Martin Friemel,Justine E. Marum,Justine E. Marum,Elena J. Tucker,Elena J. Tucker,Damien L. Bruno,Lisa G. Riley,John Christodoulou,John Christodoulou,Edwin P. Kirk,Avihu Boneh,Avihu Boneh,Christine M. DeGennaro,Michael Springer,Vamsi K. Mootha,Vamsi K. Mootha,Tracey A. Rouault,Silke Leimkühler,David R. Thorburn,David R. Thorburn,Alison G. Compton,Alison G. Compton +22 more
TL;DR: A homozygous mutation in LYRM4 in two patients with combined OXPHOS deficiency is reported, consistent with a defect in the early step of ISC assembly affecting a broad variety of Fe-S proteins.
Journal ArticleDOI
Epstein-Barr-Virus-Induced One-Carbon Metabolism Drives B Cell Transformation.
Liang Wei Wang,Hongying Shen,Luis Nobre,Ina Ersing,Joao A. Paulo,Stephen J. Trudeau,Zhonghao Wang,Nicholas A. Smith,Yijie Ma,Bryn Reinstadler,Bryn Reinstadler,Jason Nomburg,Thomas G. Sommermann,Ellen Cahir-McFarland,Steven P. Gygi,Vamsi K. Mootha,Vamsi K. Mootha,Michael P. Weekes,Benjamin E. Gewurz +18 more
TL;DR: This work highlights EBV-induced 1C as a potential therapeutic target and provides a new paradigm for viral onco-metabolism, which is highlighted in previous work on Burkitt, Hodgkin, and post-transplant B cell lymphomas.