V
Vamsi K. Mootha
Researcher at Broad Institute
Publications - 243
Citations - 90559
Vamsi K. Mootha is an academic researcher from Broad Institute. The author has contributed to research in topics: Mitochondrion & Mitochondrial DNA. The author has an hindex of 85, co-authored 227 publications receiving 73860 citations. Previous affiliations of Vamsi K. Mootha include Harvard University & Beth Israel Deaconess Medical Center.
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Journal ArticleDOI
The Mitochondrial Proteome and Human Disease
TL;DR: How the mitochondrial proteome is being used to discover the genetic basis of respiratory chain disorders as well as to expand the definition of mitochondrial disease are discussed.
Journal ArticleDOI
Editorial: Mitochondrial medicine special issue.
Posted ContentDOI
Salvage of Ribose from Uridine or RNA Supports Glycolysis when Glucose is Limiting
Alexis A. Jourdain,Owen S. Skinner,Owen S. Skinner,Owen S. Skinner,Kawakami A,Russell P. Goodman,Hongying Shen,Lajos Kemény,Joesch-Cohen L,Matthew G. Rees,Jennifer Roth,David E. Fisher,Vamsi K. Mootha,Vamsi K. Mootha,Vamsi K. Mootha +14 more
TL;DR: In this paper, the authors showed that the ribose moiety of uridine can be salvaged via a pathway called "uridinolysis" defined as: the phosphorylytic cleavage of UPP1/2 into uracil and ribose-1phosphate (R1P), the conversion of R1P into fructose-6-P and glyceraldehyde-3-P by PGM2 and the non-oxidative branch of the pentose phosphate pathway (non-oxPPP), and their glycolytic
FOXRED1, encoding an FAD-dependent oxidoreductase complex-I-specific molecular chaperone, is mutated in infantile-onset mitochondrial encephalopathy (vol 24, pg 4837, 2010)
Elisa Fassone,Andrew J. Duncan,J-W Taanman,Alistair T. Pagnamenta,Michael I. Sadowski,Tatjana Holand,Waseem Qasim,Paul Rutland,Sarah E. Calvo,Vamsi K. Mootha,Maria Bitner-Glindzicz,S Rahman +11 more
Journal ArticleDOI
Corrigendum: Large-scale chemical dissection of mitochondrial function
Bridget K. Wagner,Toshimori Kitami,Tamara J. Gilbert,David Peck,Arvind Ramanathan,Stuart L. Schreiber,Todd R. Golub,Vamsi K. Mootha +7 more
TL;DR: This article was corrected after print 8 July 2008 because the following sentence was incorrect: “Statins block the synthesis of cholesterol—a precursor to ubiquinone.”