Vandana Dahiya

TL;DR: The solvent dependent differential binding interaction of the two molecules finally indicates possibility of diverse bio-distribution of the pesticides within human body.

TL;DR: The results indicate that presence of biotin in sperm wash medium can improve the fertilization potential and preimplantation embryo development and can be considered as a safe alternate to PTX.

TL;DR: Deep insights are provided into the direct interaction of the organophosphate metabolites with a biologically important carrier protein, serum albumin, and substantial time-dependent changes in the 1H NMR intensity of PM in the presence of BSA are revealed.

TL;DR: In Vitro analysis of the interaction of organophosphate pesticides (OP) with bovine serum albumin (BSA) is crucial to understand their potential effects at the molecular level and Saturation Transfer Difference NMR experiments in conjunction with molecular docking studies revealed a high binding affinity of OP-BSA complexes through non-covalent interaction.

TL;DR: It becomes clear that although the drugs could be administered simultaneously but they influence each other’s binding with protein in a concentration dependent fashion, and it is predicted from the quenching studies that BSA-5Fluorouracil is a stronger complex than B SA-Paracetamol.