Author
Vanessa A. Tomé
Bio: Vanessa A. Tomé is an academic researcher from University of Coimbra. The author has contributed to research in topics: Phthalocyanine & Singlet oxygen. The author has an hindex of 4, co-authored 9 publications receiving 105 citations.
Papers
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TL;DR: Overall, this work aims to provide the reader with a comprehensive view of how intracellular or extracellular redox buffer systems can be assessed by using MRI contrast agents based on lanthanide or transition metal ions using T1- weighted, T2-weighted, paraCEST 1H or 19F MRI.
46 citations
TL;DR: Compound 6 has an intrinsic ability to accumulate in the tumor, adequate spectroscopic properties, and excellent stability to function as a NIR fluorescent label in the early detection of tumors.
Abstract: Diamagnetic metal complexes of phthalocyanines with n-butoxyl groups in all the α-benzo positions of the macrocycle skeleton, MPc(OBu)8, have strong near-infrared absorptions and intense fluorescences that are Stokes shifted by more than 15 nm. Interestingly, the silicon complex 6 is also remarkably photostable and nontoxic. The use of 6 in the fluorescence imaging of BALB/c mice bearing a 4T1-luc2 tumor in the mammary fat pad unambiguously revealed the presence of the tumor when it was only 1 mm in diameter and was not visible with the naked eye. Compound 6 has an intrinsic ability to accumulate in the tumor, adequate spectroscopic properties, and excellent stability to function as a NIR fluorescent label in the early detection of tumors.
44 citations
TL;DR: In this article, a review of recent strategies to synthesize meso-substituted porphyrins using alternative energy sources, reaction media and catalysts, namely microwave irradiation, water as solvent, or solid microporous acid catalysts is presented.
Abstract: The easy access and low price of pyrrole and aldehydes, conjugated with the simplicity in preparing meso-substituted porphyrins, makes this type of porphyrins very attractive for a broad range of applications. However, there is an increasing demand for the development of new synthetic processes involving more sustainable chemical principles substituting, whenever possible, dangerous organic solvents by alternative solvents, chromatographic purifications by precipitations and energy-intensive procedures by alternative energy sources such as microwaves and ultrasounds. In this review we will address some recent strategies to synthesize meso-substituted porphyrins using alternative energy sources, reaction media and catalysts, namely microwave irradiation, water as solvent, or solid microporous acid catalysts.
25 citations
TL;DR: Water soluble phthalocyanines bearing either four PEG500 or four choline substituents in the macrocyclic structure, as well as their Zn(II) and Mn(III) complexes were synthesized and the effect of DMSO on the aggregation of the phthalcyanines was studied.
21 citations
TL;DR: It is shown that a ring-deformed indium phthalocyanine (InPc) with a strong absorption band at ∼840 nm is a promising photoacoustic probe, while presents adequate photostability for imaging, very fast and efficient radiationless processes, and negligible cytotoxicity or phototoxicity in vitro up to concentrations of 30 µM.
6 citations
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TL;DR: This Review gives emphasis to the nonlinear optical properties of photoactive materials for the function of optical power limiting and describes the known mechanisms of optical limiting for the different types of materials.
Abstract: The control of luminous radiation has extremely important implications for modern and future technologies as well as in medicine. In this Review, we detail chemical structures and their relevant photophysical features for various groups of materials, including organic dyes such as metalloporphyrins and metallophthalocyanines (and derivatives), other common organic materials, mixed metal complexes and clusters, fullerenes, dendrimeric nanocomposites, polymeric materials (organic and/or inorganic), inorganic semiconductors, and other nanoscopic materials, utilized or potentially useful for the realization of devices able to filter in a smart way an external radiation. The concept of smart is referred to the characteristic of those materials that are capable to filter the radiation in a dynamic way without the need of an ancillary system for the activation of the required transmission change. In particular, this Review gives emphasis to the nonlinear optical properties of photoactive materials for the functi...
424 citations
TL;DR: The most recent research performed on metalloporphyrin-based materials in photodynamic therapy, photodynamic inactivation of microorganisms, photodiagnosis and drug delivery are explored, demonstrating their perspectives for biomedical applications.
200 citations
TL;DR: This review focuses on the application of porphyrins in the photo-inactivation of bacteria and Mechanisms of bacterial resistance and some of the current ‘greener’ methods of synthesis of meso-phenyl p Morphyrins are discussed.
Abstract: Antibiotics are commonly used to control, treat, or prevent bacterial infections, however bacterial resistance to all known classes of traditional antibiotics has greatly increased in the past years especially in hospitals rendering certain therapies ineffective. To limit this emerging public health problem, there is a need to develop non-incursive, non-toxic, and new antimicrobial techniques that act more effectively and quicker than the current antibiotics. One of these effective techniques is antibacterial photodynamic therapy (aPDT). This review focuses on the application of porphyrins in the photo-inactivation of bacteria. Mechanisms of bacterial resistance and some of the current ‘greener’ methods of synthesis of meso-phenyl porphyrins are discussed. In addition, significance and limitations of aPDT are also discussed. Furthermore, we also elaborate on the current clinical applications and the future perspectives and directions of this non-antibiotic therapeutic strategy in combating infectious diseases.
149 citations
TL;DR: Recently reported NIR emitting organic/inorganic fluorophores that targets and accumulates in organelle/organs specifically for molecular imaging of cancerous cells are reviewed.
138 citations
TL;DR: In this paper, the authors analyze and discuss the literature concerning the application of metal-based hybrid materials as heterogeneous photocatalysts for downstream depletion of antibiotics through advanced oxidation processes (AOP) using semiconductor photosensitization or photo-Fenton oxidation processes.
115 citations