V
Vanessa Castelli
Researcher at University of L'Aquila
Publications - 72
Citations - 1412
Vanessa Castelli is an academic researcher from University of L'Aquila. The author has contributed to research in topics: Medicine & Neuroprotection. The author has an hindex of 15, co-authored 58 publications receiving 661 citations. Previous affiliations of Vanessa Castelli include University of South Florida.
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Journal ArticleDOI
Neuronal Cells Rearrangement During Aging and Neurodegenerative Disease: Metabolism, Oxidative Stress and Organelles Dynamic.
Vanessa Castelli,Elisabetta Benedetti,Andrea Antonosante,Mariano Catanesi,Giuseppina Pitari,Rodolfo Ippoliti,Annamaria Cimini,Annamaria Cimini,Michele d'Angelo +8 more
TL;DR: The first part of the review article will focus on the major neuronal cells’ rearrangements during aging in response to changes in metabolism and oxidative stress, while the second part will cover the neurodegenerative disease areas in detail.
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Cytokine Storm in COVID-19: "When You Come Out of the Storm, You Won't Be the Same Person Who Walked in".
TL;DR: The role of cytokine storm in COVID-19 and potential treatments with which to counteract this aberrant response, which may be valuable in the clinical translation are discussed.
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Effects of the probiotic formulation SLAB51 in in vitro and in vivo Parkinson's disease models.
Vanessa Castelli,Michele d'Angelo,Francesca Lombardi,Margherita Alfonsetti,Andrea Antonosante,Mariano Catanesi,Elisabetta Benedetti,Paola Palumbo,Maria Grazia Cifone,Antonio Giordano,Antonio Giordano,Giovambattista Desideri,Annamaria Cimini,Annamaria Cimini +13 more
TL;DR: The findings indicate that this probiotic formulation can counteract the detrimental effect of 6-OHDA in vitro and in vivo models of PD, and suggest that SLAB51 can be a promising candidate for the prevention or as coadjuvant treatment of PD.
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The Role of Stiffness in Cell Reprogramming: A Potential Role for Biomaterials in Inducing Tissue Regeneration.
Michele d'Angelo,Elisabetta Benedetti,Maria Grazia Tupone,Mariano Catanesi,Vanessa Castelli,Andrea Antonosante,Annamaria Cimini +6 more
TL;DR: This work presents the most relevant mechanism by which the biomechanical properties of extracellular matrix (ECM) influence cell reprogramming, with particular attention on the new technologies and materials engineering, in which are taken into account not only the biochemical and biophysical signals patterns but also the factor time.
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MicroRNAs Dysregulation and Mitochondrial Dysfunction in Neurodegenerative Diseases.
Mariano Catanesi,Michele d'Angelo,Maria Grazia Tupone,Elisabetta Benedetti,Antonio Giordano,Antonio Giordano,Vanessa Castelli,Annamaria Cimini,Annamaria Cimini +8 more
TL;DR: A focus is placed on miRNAs and their role in mitochondrial dysfunction in aging-related neurodegenerative diseases, with a focus on their potential as diagnostic biomarkers and therapeutic targets.