V
Vardhman K. Rakyan
Researcher at Queen Mary University of London
Publications - 72
Citations - 10955
Vardhman K. Rakyan is an academic researcher from Queen Mary University of London. The author has contributed to research in topics: DNA methylation & Epigenetics. The author has an hindex of 37, co-authored 67 publications receiving 9848 citations. Previous affiliations of Vardhman K. Rakyan include Wellcome Trust Sanger Institute & University of Sydney.
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Journal ArticleDOI
DNA methylation profiling of human chromosomes 6, 20 and 22
Florian Eckhardt,Joern Lewin,Rene Cortese,Vardhman K. Rakyan,John Attwood,Matthias Burger,John Burton,Tony Cox,Robert L. Davies,Thomas A. Down,Carolina Haefliger,Roger Horton,Kevin L. Howe,David K. Jackson,Jan Kunde,Jan Kunde,Christoph Koenig,Jennifer Liddle,David Niblett,Thomas J. Otto,Roger Pettett,Stefanie Seemann,Christian Thompson,Tony West,Jane Rogers,Alex Olek,Kurt Berlin,Stephan Beck +27 more
TL;DR: Analysis of six annotation categories showed that evolutionarily conserved regions are the predominant sites for differential DNA methylation and that a core region surrounding the transcriptional start site is an informative surrogate for promoter methylation.
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Epigenome-wide association studies for common human diseases
TL;DR: This work discusses EWAS design, cohort and sample selections, statistical significance and power, confounding factors and follow-up studies, and how integration of EWASs with GWASs can help to dissect complex GWAS haplotypes for functional analysis.
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Human aging-associated DNA hypermethylation occurs preferentially at bivalent chromatin domains
Vardhman K. Rakyan,Thomas A. Down,Siarhei Maslau,Toby Andrew,Tsun-Po Yang,Huriya Beyan,Pamela Whittaker,O. T. McCann,Sarah Finer,Ana M. Valdes,R. David Leslie,Panogiotis Deloukas,Tim D. Spector +12 more
TL;DR: This work reports the first genome-scale study of epigenomic dynamics during normal human aging, identifying aging-associated differentially methylated regions (aDMRs) in whole blood and demonstrating that the aDMR signature is a multitissue phenomenon.
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A Bayesian deconvolution strategy for immunoprecipitation-based DNA methylome analysis
Thomas A. Down,Vardhman K. Rakyan,Daniel J. Turner,Paul Flicek,Heng Li,Eugene Kulesha,Stefan Gräf,Nathan Johnson,Javier Herrero,Eleni M. Tomazou,Natalie P. Thorne,Liselotte Bäckdahl,Marlis Herberth,Kevin L. Howe,David K. Jackson,Marcos Mateo Miretti,John C. Marioni,Ewan Birney,Tim Hubbard,Richard Durbin,Simon Tavaré,Stephan Beck +21 more
TL;DR: This work has developed a cross-platform algorithm—Bayesian tool for methylation analysis (Batman)—for analyzing methylated DNA immunoprecipitation profiles generated using oligonucleotide arrays or next-generation sequencing, developed to provide a high-resolution whole-genome DNA methylation profile (DNA methylome) of a mammalian genome.
Journal ArticleDOI
Transgenerational inheritance of epigenetic states at the murine AxinFu allele occurs after maternal and paternal transmission
Vardhman K. Rakyan,Suyinn Chong,Marnie E. Champ,Peter C. Cuthbert,Hugh Morgan,Keith V. K. Luu,Emma Whitelaw +6 more
TL;DR: It is found that the methylation state of AxinFu in mature sperm reflects the methylated state of the allele in the somatic tissue of the animal, suggesting that it does not undergo epigenetic reprogramming during gametogenesis, and it is shown that epigenetic inheritance is influenced by strain background.