V
Vasant Muralidharan
Researcher at University of Georgia
Publications - 41
Citations - 1618
Vasant Muralidharan is an academic researcher from University of Georgia. The author has contributed to research in topics: Plasmodium falciparum & Endoplasmic reticulum. The author has an hindex of 14, co-authored 38 publications receiving 1415 citations. Previous affiliations of Vasant Muralidharan include Stony Brook University & Washington University in St. Louis.
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Journal ArticleDOI
Protein ligation: an enabling technology for the biophysical analysis of proteins
Vasant Muralidharan,Tom W. Muir +1 more
TL;DR: Some guidelines for the use of EPL and PTS are provided, and how the dovetailing of these new protein chemistry methods with standard biophysical techniques has improved the ability to interrogate protein function, structure and folding are highlighted.
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Plasmepsin V licenses Plasmodium proteins for export into the host erythrocyte
Ilaria Russo,Ilaria Russo,Shalon E. Babbitt,Vasant Muralidharan,Tamira Butler,Anna Oksman,Daniel E. Goldberg +6 more
TL;DR: It is proposed that plasmepsin V, an ER aspartic protease with distant homology to the mammalian processing enzyme BACE, is the PEXEL protease and is an attractive enzyme for antimalarial drug development.
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PTEX component HSP101 mediates export of diverse malaria effectors into host erythrocytes
TL;DR: It is shown that export across the PVM requires heat shock protein 101 (HSP101), a ClpB-like AAA+ ATPase component of PTEX, and strong evidence is provided for PTEX function in protein translocation into the host cell.
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Asparagine repeat function in a Plasmodium falciparum protein assessed via a regulatable fluorescent affinity tag.
TL;DR: A regulatable, fluorescent affinity (RFA) tag that allows cellular localization, manipulation of cellular levels, and affinity isolation of a chosen protein in P. falciparum is developed to facilitate study of the role of essential genes in parasite biology.
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Plasmodium falciparum heat shock protein 110 stabilizes the asparagine repeat-rich parasite proteome during malarial fevers.
Vasant Muralidharan,Vasant Muralidharan,Anna Oksman,Priya Pal,Susan Lindquist,Susan Lindquist,Daniel E. Goldberg +6 more
TL;DR: It is concluded that PfHsp110c protects the parasite from harmful effects of its asparagine repeat-rich proteome during febrile episodes.