V
Veerakumar Balasubramaniyan
Researcher at University of Texas MD Anderson Cancer Center
Publications - 39
Citations - 2731
Veerakumar Balasubramaniyan is an academic researcher from University of Texas MD Anderson Cancer Center. The author has contributed to research in topics: Glioma & Neural stem cell. The author has an hindex of 18, co-authored 35 publications receiving 2221 citations. Previous affiliations of Veerakumar Balasubramaniyan include University of Texas Health Science Center at Houston & University of Groningen.
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Journal ArticleDOI
Mesenchymal Differentiation Mediated by NF-κB Promotes Radiation Resistance in Glioblastoma
Krishna P.L. Bhat,Veerakumar Balasubramaniyan,Brian Vaillant,Ravesanker Ezhilarasan,Karlijn Hummelink,Faith Hollingsworth,Khalida Wani,Lindsey Heathcock,Johanna D. James,Lindsey D. Goodman,Siobhan Conroy,Lihong Long,Nina Lelic,Suzhen Wang,Joy Gumin,Divya Raj,Yoshinori Kodama,Aditya Raghunathan,Adriana Olar,Kaushal Joshi,Christopher E. Pelloski,Amy B. Heimberger,Se Hoon Kim,Daniel P. Cahill,Ganesh Rao,Wilfred F. A. den Dunnen,Hendrikus Boddeke,Heidi S. Phillips,Ichiro Nakano,Frederick F. Lang,Howard Colman,Erik P. Sulman,Kenneth Aldape +32 more
TL;DR: It is shown that patient-derived glioma sphere cultures that resemble either the proneural (PN) or mesenchymal (MES) transcriptomal subtypes differ significantly in their biological characteristics, and it is suggested that the tumor microenvironment cell types such as macrophages/microglia may play an integral role in this process.
Journal ArticleDOI
The transcriptional coactivator TAZ regulates mesenchymal differentiation in malignant glioma
Krishna P.L. Bhat,Krishna P.L. Bhat,Katrina Salazar,Katrina Salazar,Veerakumar Balasubramaniyan,Veerakumar Balasubramaniyan,Veerakumar Balasubramaniyan,Khalida Wani,Lindsey Heathcock,Faith Hollingsworth,Johanna D. James,Joy Gumin,Kristin Diefes,Se Hoon Kim,Se Hoon Kim,Alice Turski,Yasaman Azodi,Yuhui Yang,Tiffany Doucette,Howard Colman,Erik P. Sulman,Frederick F. Lang,Ganesh Rao,Sjef Copray,Brian Vaillant,Kenneth Aldape +25 more
TL;DR: These studies uncover a direct role for TAZ and TEAD in driving the MES differentiation of malignant glioma.
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Hypoxia enhances migration and invasion in glioblastoma by promoting a mesenchymal shift mediated by the HIF1α-ZEB1 axis
Justin V. Joseph,Siobhan Conroy,Kirill Pavlov,Pallavi Sontakke,Tushar Tomar,Ellie Eggens-Meijer,Veerakumar Balasubramaniyan,Michiel Wagemakers,Wilfred F. A. den Dunnen,Frank A.E. Kruyt +9 more
TL;DR: A HIF1α-ZEB1 signaling axis that promotes hypoxia induced mesenchymal shift and invasion in GBM in a cell line dependent fashion is identified.
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Single-cell analyses reveal increased intratumoral heterogeneity after the onset of therapy resistance in small-cell lung cancer.
C. Allison Stewart,Yuanxin Xi,Santhosh Sivajothi,V. Sivakamasundari,Junya Fujimoto,Mohan Bolisetty,Patrice M. Hartsfield,Veerakumar Balasubramaniyan,Milind D. Chalishazar,Cesar A. Moran,Neda Kalhor,John Stewart,Hai T. Tran,Stephen G. Swisher,Jack A. Roth,Jianjun Zhang,John de Groot,Bonnie S. Glisson,Trudy G. Oliver,John V. Heymach,Ignacio I. Wistuba,Paul Robson,Jing Wang,Lauren Averett Byers +23 more
TL;DR: The data suggest that treatment-resistance in SCLC is characterized by coexisting subpopulations of cells with heterogeneous gene expression leading to multiple, concurrent resistance mechanisms, which emphasize the need for clinical efforts to focus on rational combination therapies for treatment-naïve SclC tumors to maximize initial responses and counteract the emergence of ITH and diverse resistance mechanisms.
Journal ArticleDOI
Differentiation of Neural Stem Cells into Oligodendrocytes: Involvement of the Polycomb Group Protein Ezh2
Falak Sher,Reinhard Rossler,Nieske Brouwer,Veerakumar Balasubramaniyan,Erik Boddeke,Sjef Copray +5 more
TL;DR: The expression of Ezh2 decreased when the NSCs differentiated into neurons and was completely suppressed during differentiation into astrocytes, whereas low levels of EzH2 led to completely opposite effects, which could be ascribed to stimulation of OPC proliferation although stimulation of oligodendrocyte differentiation cannot be excluded.