Bio: Venkatachalapathi A is an academic researcher. The author has contributed to research in topics: Forskolin & Glomus. The author has an hindex of 3, co-authored 8 publications receiving 30 citations.
TL;DR: The present study aimed to explore the traditional knowledge of Irula tribal people who are practicing herbal medicine in Walayar valley, the Southern Western Ghats, India and identified 146 species of plants identified as commonly used ethnomedicinal plants by them.
TL;DR: Investigation of the antiinflammatory and antioxidant potential of crude methanol leaf extract and the isolated compound, forskolin from S. amplexicaulis suggest that it is considered to be a valuable source of remedy for inflammation.
Abstract: Leaves of Solena amplexicaulis are traditionally used as a remedy for the treatment of inflammation related disorders in the form of decoction by the Paliyar tribal community of Theni district, Tamil Nadu, India. This study was designed to investigate the antiinflammatory and antioxidant potential of crude methanol leaf extract and the isolated compound, forskolin from S. amplexicaulis. Their effects were evaluated by carrageenan-induced paw edema in experimental rats for 4 h. In vivo antioxidant and histopathological studies were also performed. Therapeutic potential of forskolin was further substantiated using PASS software. The oral administration of forskolin (10 mg/kg) exerted potent antiinflammatory activity by reducing paw edema (87.79%) than the crude extract (150 and 300 mg/kg) and it was comparable with the standard drug, indomethacin (10 mg/kg, 93.89%). Consistent with these findings, antioxidant, histopathological architecture and PASS software also reflected its prominent curative property. The obtained results therefore suggest that the compound, forskolin obtained from S. amplexicaulis is considered to be a valuable source of remedy for inflammation.
TL;DR: The biochemical observations as well as the histopathological examination of liver sections manifested considerable hepatoprotective activity of B. malabarica stem bark, and thus validated the folkloric claim.
30 Dec 2018
Abstract: In the present research work was to examine the possible antioxidant activities of the aqueous and ethanol leaf extract of Rhinacanthus nasutus (Linn.) Kurz. DPPH, Hydroxyl radical scavenging and reducing power assays were employed. The results showed that the DPPH activity of aqueous and ethanol leaf extract at the dose of 50μg/ml has exhibited in 63.81±0.013 and 79.36±0.028 inhibition with an IC50 value of 21.39 and 29.41μg/ml. The highest Hydroxyl radical scavenging activity showed aqueous and ethanol leaf extract at the dose of 50μg/ml has exhibited in 96.18±0.029 and 121.23±0.081 inhibition with an IC50 values of 30.19and 41.39μg/ml, the reducing power assay aqueous and ethanol leaf extract showed the 0.59 and 0.71 absorption at 700 nm extract at the dose of 50μg/ml suggested that promising antioxidant activity of crude aqueous and ethanol extract could be used as a source of natural antioxidants of R. nasutus and needs further studies to bring new natural products into pharmaceutical industries.
30 Dec 2017
TL;DR: Rhizophagus fasciculatus was found to be most abundant species and this symbiotic relationship had important roles in establishment of plant community of this area and conform the rich diversity in the study area.
Abstract: The ecological mechanisms of AM fungal diversity ensure successful management for conservation and restoration of natural ecosystems. Here the study contacted to estimate the diversity of AM fungal and their function in Velliangiri hills, Western Ghats, Coimbatore. The community structure of AM fungi, as determined by number of spores present in 100g of soil, varied with sampling time in plant community. And all so the morphological identification was done by microscopic characters. Soil properties like pH, macro and micro nutrient and the climate data were collected for all tree years to know their impact on fungal community. The overall result conform the root colonization and spore population were higher in winter season and also lower in rainy. Totally 30 AM fungal species from 10 genera were identified the important genera were Acaulospora, Ambispora, Claroideoglomus, Funneliformis, Gigaspora, Glomus, Racocetra, Redeckera, Rhizophagus and Scutellospora. Among these five genera, Glomus occurred most frequently. In general, Rhizophagus fasciculatus was found to be most abundant species. Consequently, this result conform the rich diversity in the study area. This symbiotic relationship had important roles in establishment of plant community of this area.
TL;DR: P. nigrum should not only be regarded as “King of spices” but can also be considered as part of the kingdom of medicinal agents, comprising a panoply of bioactive compounds with potential nutraceutical and pharmaceutical applications.
Abstract: Considered as the “King of spices”, black pepper (Piper nigrum L.) is a widely used spice which adds flavor of its own to dishes, and also enhances the taste of other ingredients. Piper nigrum has ...
TL;DR: A good lifestyle, regular exercise, avoidance of stress and observing safety rules at work are habits that can reverse male infertility.
Abstract: Defective sperm function has been identified as the most common cause of infertility. The objective of this study was to review recent findings on the effects of various antioxidants on male fertility. High amounts of poly unsaturated fatty acid are found in the mammalian spermatozoa membranes, thereby making them susceptible to lipid peroxidation. Although, free radicals and reactive oxygen species (ROS) play major roles in reproduction, they are strongly associated with oxidative stress. Furthermore, factors such as obesity, inflammation, pollutants and cigarette smoking are negatively correlated with spermatogenesis. Endogenous antioxidants system exists to mediate these damages. In a normal physiological state, the seminal plasma contains antioxidant enzyme mechanism that is capable of quenching these ROS as well as protecting the spermatozoa against any likely damage. However, high level of ROS triggered by inflammatory cells and oxidation of fatty acid in obese subjects may down play antioxidant mechanism resulting in oxidative stress. Evaluation of such oxidative stress is the first step in the treatment of male infertility through administration of suitable antioxidant. Notably, antioxidant such as vitamin E and C, carotenoids and carnitine have been found beneficial in restoring a balance between ROS generation and scavenging activities. There are emerging evidences that herbal products can also boost male reproductive functions. Nonetheless, a good lifestyle, regular exercise, avoidance of stress and observing safety rules at work are habits that can reverse male infertility.
TL;DR: This article provides extensive coverage of naturally occurring labdane diterpenes, discovered between 1981 and 2016, which have been verified as NF‐&kgr;B, NO, or AA modulators.
TL;DR: In this article, a comprehensive summary of the geographical distribution, traditional use, phytochemistry, and pharmacological activities of W. somnifera and its active constituents are presented.