Venus Lai

TL;DR: Two genes encode ubiquitin ligases that are potential drug targets for the treatment of muscle atrophy, and mice deficient in either MAFbx orMuRF1 were found to be resistant to atrophy.

TL;DR: It is demonstrated that lncRNAs play critical roles in vivo and provides a framework and impetus for future larger-scale functional investigation into the roles of lncRNA molecules.

TL;DR: The preclinical characterization of REGN2810 is described, a fully human hinge-stabilized IgG4(S228P) high-affinity anti–PD-1 antibody that potently blocks PD-1 interactions with PD-L1 andPD-L2, validating it as a potent and promising candidate for cancer immunotherapy.

TL;DR: The mechanism of action and robust anti-tumor efficacy of REGN2810 support its clinical development for the treatment of human cancers.

TL;DR: Robust anti-tumor efficacy of REGN2810 and anti-hLAG-3 combination in preclinical setting supports their clinical development as a combination cancer immunotherapy.