V
Vesna Jevtovic-Todorovic
Researcher at University of Colorado Denver
Publications - 163
Citations - 12485
Vesna Jevtovic-Todorovic is an academic researcher from University of Colorado Denver. The author has contributed to research in topics: Neurotoxicity & Nociception. The author has an hindex of 55, co-authored 146 publications receiving 11278 citations. Previous affiliations of Vesna Jevtovic-Todorovic include University of Virginia Health System & University of Colorado Boulder.
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Journal ArticleDOI
Early Exposure to Common Anesthetic Agents Causes Widespread Neurodegeneration in the Developing Rat Brain and Persistent Learning Deficits
Vesna Jevtovic-Todorovic,Richard E. Hartman,Yukitoshi Izumi,N. Benshoff,Krikor Dikranian,Charles F. Zorumski,John W. Olney,David F. Wozniak +7 more
TL;DR: A combination of drugs commonly used in pediatric anesthesia in doses sufficient to maintain a surgical plane of anesthesia is administered to 7-d-old infant rats, and it is observed that this causes widespread apoptotic neurodegeneration in the developing brain, deficits in hippocampal synaptic function, and persistent memory/learning impairments.
Journal ArticleDOI
Nitrous oxide (laughing gas) is an NMDA antagonist, neuroprotectant and neurotoxin
Vesna Jevtovic-Todorovic,Slobodan M. Todorovic,Steven Mennerick,S Powell,Krikor Dikranian,N. Benshoff,Charles F. Zorumski,John W. Olney +7 more
TL;DR: It is shown that N2O, at anesthetically-relevant concentrations, inhibits both ionic currents and excitotoxic neurodegeneration mediated through NMDA receptors and, like other NMDA antagonists, produces neurotoxic side effects which can be prevented by drugs that enhance CABAergic inhibition.
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Ketamine-Induced NMDA Receptor Hypofunction as a Model of Memory Impairment and Psychosis
John W. Newcomer,Nuri B. Farber,Vesna Jevtovic-Todorovic,Gregg Selke,Angela K. Melson,Tamara Hershey,Suzanne Craft,John W. Olney +7 more
TL;DR: This double-blind, placebo-controlled, randomized, within-subjects comparison of three fixed subanesthetic, steady-state doses of intravenous ketamine in healthy males demonstrated dose-dependent increases in Brief Psychiatric Rating Scale positive and negative symptoms.
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Anesthesia induces neuronal cell death in the developing rat brain via the intrinsic and extrinsic apoptotic pathways
TL;DR: To understand the mechanism by which general anesthetics induce apoptotic neuronal death, two common apoptotic pathways are studied--the intrinsic and the extrinsic pathway--at different time points during synaptogenesis.
Journal ArticleDOI
Potential of ketamine and midazolam, individually or in combination, to induce apoptotic neurodegeneration in the infant mouse brain.
Chainllie Young,Vesna Jevtovic-Todorovic,Yue-Qin Qin,Tatyana Tenkova,Haihui Wang,Joann Labruyere,John W. Olney +6 more
TL;DR: It is concluded that relatively mild exposure to ketamine, midazolam or a combination of these drugs can trigger apoptotic neurodegeneration in the developing mouse brain.