Vianne R. Gao

TL;DR: The Human Tumor Atlas Network (HTAN), part of the NCI Cancer Moonshot Initiative, will establish a clinical, experimental, computational, and organizational framework to generate informative and accessible three-dimensional atlases of cancer transitions for a diverse set of tumor types.

TL;DR: In this article, the heterogeneity of small cell lung cancer (SCLC) is defined by differential expression of ASCL1, NEUROD1, and POU2F3.

TL;DR: Heterogeneity of synovial fibroblasts in inflamed joints of rheumatoid arthritis patients is explored using paired single cell RNA and ATAC sequencing, multiplexed imaging, and spatial transcriptomics along with in vitro modeling of cell extrinsic factor signaling to highlight a role for concurrent, spatially distributed cytokine signaling within the inflamed synovium.

TL;DR: Burdziak et al. as mentioned in this paper investigated the origins and impact of epigenetic plasticity during early neoplasia in the development of pancreatic cancer using single-cell analyses on normal, inflamed, premalignant, and malignant tissues in autochthonous models.

TL;DR: In this article , single-cell analyses on normal, inflamed, pre-malignant and malignant tissues in autochthonous models of pancreatic cancer were performed to investigate the origins and impact of epigenetic plasticity.