V
Victor Bigira
Researcher at Makerere University
Publications - 30
Citations - 854
Victor Bigira is an academic researcher from Makerere University. The author has contributed to research in topics: Malaria & Dihydroartemisinin/piperaquine. The author has an hindex of 15, co-authored 29 publications receiving 743 citations. Previous affiliations of Victor Bigira include Mulago Hospital & University of California, San Francisco.
Papers
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Journal ArticleDOI
Polymorphisms in K13 and Falcipain-2 Associated with Artemisinin Resistance Are Not Prevalent in Plasmodium falciparum Isolated from Ugandan Children
Melissa D. Conrad,Victor Bigira,James Kapisi,Mary K. Muhindo,Moses R. Kamya,Diane V. Havlir,Grant Dorsey,Philip J. Rosenthal +7 more
TL;DR: The prevalence of K13-propeller and FP2 polymorphisms did not increase over time, and was not associated with either time since prior receipt of an ACT or the persistence of parasites ≥2 days following treatment with an ACT, indicating that artemisinin resistance is not prevalent in Uganda.
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Comparative Impacts Over 5 Years of Artemisinin-Based Combination Therapies on Plasmodium falciparum Polymorphisms That Modulate Drug Sensitivity in Ugandan Children
Melissa D. Conrad,Norbert P. LeClair,Emmanuel Arinaitwe,Humphrey Wanzira,Abel Kakuru,Victor Bigira,Mary K. Muhindo,Moses R. Kamya,Jordan W. Tappero,Bryan Greenhouse,Grant Dorsey,Philip J. Rosenthal +11 more
TL;DR: Genotypes with decreased sensitivity to AL components increased over time, suggesting that the choice of treatment regimen can profoundly influence parasite genetics and drug sensitivity.
Journal ArticleDOI
Protective Efficacy and Safety of Three Antimalarial Regimens for the Prevention of Malaria in Young Ugandan Children: A Randomized Controlled Trial
Victor Bigira,James Kapisi,Tamara D. Clark,Stephen Kinara,Florence Mwangwa,Mary K. Muhindo,Beth Osterbauer,Francesca T. Aweeka,Liusheng Huang,Jane Achan,Diane V. Havlir,Philip J. Rosenthal,Moses R. Kamya,Grant Dorsey +13 more
TL;DR: The efficacy of three antimalarial drugs for preventing malaria in children living in Uganda, an area of high transmission intensity, is investigated.
Journal ArticleDOI
Poor housing construction associated with increased malaria incidence in a cohort of young Ugandan children.
Katherine Snyman,Florence Mwangwa,Victor Bigira,James Kapisi,Tamara D. Clark,Beth Osterbauer,Bryan Greenhouse,Hugh J. W. Sturrock,Roly Gosling,Jenny Liu,Grant Dorsey +10 more
TL;DR: Living in a modern house, defined as the use of non-earth floors, non-thatched roofs, and non-mud walls, was associated with approximately half malaria incidence compared with living in a traditional home, adding to the growing body of evidence that improved house construction may be associated with a lower risk of malaria.
Journal ArticleDOI
Impact of antimalarial treatment and chemoprevention on the drug sensitivity of malaria parasites isolated from ugandan children.
Patrick K Tumwebaze,Melissa D. Conrad,Andrew Walakira,Norbert P. LeClair,Oswald Byaruhanga,Christine Nakazibwe,Benjamin Kozak,Jessica Bloome,Jaffer Okiring,Abel Kakuru,Victor Bigira,James Kapisi,Jennifer Legac,Jiri Gut,Roland A. Cooper,Moses R. Kamya,Diane V. Havlir,Grant Dorsey,Bryan Greenhouse,Samuel L. Nsobya,Philip J. Rosenthal +20 more
TL;DR: Overall, changes in parasite sensitivity were consistent with altered selective pressures due to changing treatment practices in Uganda and may threaten the antimalarial treatment and preventive efficacies of artemether-lumefantrine and dihydroartemisinin-piperaquine, respectively.