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Victor Caryl Myers

Bio: Victor Caryl Myers is an academic researcher. The author has contributed to research in topics: Creatine & Creatinine. The author has an hindex of 3, co-authored 4 publications receiving 43 citations.


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Book ChapterDOI
01 Jan 1961
TL;DR: The pathways of purine and pyrimidine metabolism have been greatly aided by tracer research, nutritional and genetic studies with intact organisms, and tissue studies in vitro as mentioned in this paper, and their biosynthesis was complicated by the increased formation of free bases from the breakdown of tissue nucleic acids and nucleotides upon homogenization of the tissue.
Abstract: Publisher Summary This chapter provides an overview of purines and pyrimidines and their biosynthesis. The pathways of purine and pyrimidine metabolism have been greatly aided by tracer research, nutritional and genetic studies with intact organisms, and tissue studies in vitro. The study of purine synthetic reactions was complicated by the increased formation of purine bases from the breakdown of tissue nucleic acids and nucleotides upon homogenization of the tissue. The utilization of free purines is accomplished by reaction with PRPP to form nucleotides directly. The bases have also been converted to nucleotides via the nucleosides. Nucleosides are produced by reaction of free bases with ribose 1-phosphate in the presence of nucleoside phosphorylase. The extensive utilization of dietary adenine and the nonutilization of guanine in rat have been explained in terms of the relative absence of the enzyme adenase and the presence of much guanase in rat tissues. The synthesis of purines de novo was initiated by the formation of 5-phosphoribosylamine by reaction of glutamine with 5-phosphoribosylpyrophosphate. The nucleotides that are constituents of nucleic acids, namely, guanylic acid and adenylic acid, were formed from inosinic acid.

250 citations