V
Victor R. Ambros
Researcher at University of Massachusetts Medical School
Publications - 129
Citations - 51720
Victor R. Ambros is an academic researcher from University of Massachusetts Medical School. The author has contributed to research in topics: Caenorhabditis elegans & Gene. The author has an hindex of 60, co-authored 127 publications receiving 48521 citations. Previous affiliations of Victor R. Ambros include Swedish University of Agricultural Sciences & Massachusetts Institute of Technology.
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The C. elegans heterochronic gene lin-4 encodes small RNAs with antisense complementarity to lin-14
TL;DR: Two small lin-4 transcripts of approximately 22 and 61 nt were identified in C. elegans and found to contain sequences complementary to a repeated sequence element in the 3' untranslated region (UTR) of lin-14 mRNA, suggesting that lin- 4 regulates lin- 14 translation via an antisense RNA-RNA interaction.
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The functions of animal microRNAs
TL;DR: Evidence is mounting that animal miRNAs are more numerous, and their regulatory impact more pervasive, than was previously suspected.
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Efficient gene transfer in C.elegans: extrachromosomal maintenance and integration of transforming sequences.
TL;DR: A dominant behavioral marker, rol‐6(su‐1006), and an efficient microinjection procedure which facilitate the recovery of Caenorhabditis elegans transformants are described and it is shown that low copy number extrachromosomal transformation can be achieved by adjusting the relative concentration of DNA molecules in the injection mixture.
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An Extensive Class of Small RNAs in Caenorhabditis elegans
Rosalind C. Lee,Victor R. Ambros +1 more
TL;DR: Using bioinformatics and cDNA cloning, this work found 15 new miRNA genes in C. elegans that express small transcripts that vary in abundance during larval development, and three of them have apparent homologs in mammals and/or insects.
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A uniform system for microRNA annotation
Victor R. Ambros,Bonnie Bartel,David P. Bartel,Christopher B. Burge,James C. Carrington,Xuemei Chen,Gideon Dreyfuss,Sean R. Eddy,Sam Griffiths-Jones,Mhairi Marshall,Marjori Matzke,Gary Ruvkun,Thomas Tuschl +12 more
TL;DR: Guidelines are presented for the identification and annotation of new miRNAs from diverse organisms, particularly so that mi RNAs can be reliably distinguished from other RNAs such as small interfering RNAs.