V
Vidyasiri Vemulapalli
Researcher at Harvard University
Publications - 15
Citations - 925
Vidyasiri Vemulapalli is an academic researcher from Harvard University. The author has contributed to research in topics: Methylation & Protein tyrosine phosphatase. The author has an hindex of 10, co-authored 13 publications receiving 724 citations. Previous affiliations of Vidyasiri Vemulapalli include University of Texas MD Anderson Cancer Center.
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Journal ArticleDOI
Immunoaffinity Enrichment and Mass Spectrometry Analysis of Protein Methylation
Ailan Guo,Hongbo Gu,Jing Zhou,Daniel Mulhern,Yi Wang,Kimberly Lee,Vicky Yang,Mike Aguiar,Jon M. Kornhauser,Xiaoying Jia,Jianmin Ren,Sean A. Beausoleil,Jeffrey C. Silva,Vidyasiri Vemulapalli,Mark T. Bedford,Michael J. Comb +15 more
TL;DR: The number of methylation sites identified in this study exceeds those found in the literature to date, and extends the types of proteins that are known to be arginine methylated to include many new protein types.
Journal ArticleDOI
Loss of the major Type I arginine methyltransferase PRMT1 causes substrate scavenging by other PRMTs
Surbhi Dhar,Vidyasiri Vemulapalli,Alexander N. Patananan,Grace L. Huang,Alessandra Di Lorenzo,Stéphane Richard,Michael J. Comb,Ailan Guo,Steven Clarke,Mark T. Bedford +9 more
TL;DR: It is shown that with the loss of PRMT1 activity, there are major increases in global MMA and SDMA levels, as detected by type-specific antibodies, and the pre-existence of the dominant ADMA mark can block the occurrence of SDMA and MMA marks on the same substrate.
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Structural reorganization of SHP2 by oncogenic mutations and implications for oncoprotein resistance to allosteric inhibition
Jonathan R. LaRochelle,Michelle Fodor,Vidyasiri Vemulapalli,Morvarid Mohseni,Ping Wang,Travis Stams,Matthew J. LaMarche,Rajiv Chopra,Michael G. Acker,Stephen C. Blacklow +9 more
TL;DR: The crystal structure ofSHP2E76K, the most frequent cancer-associated SHP2 mutation, is presented, which adopts an open-state structure and it is shown that the allosteric inhibitor SHP099 can revert SHP 2E76k to its closed, autoinhibited conformation.
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Identification of an allosteric benzothiazolopyrimidone inhibitor of the oncogenic protein tyrosine phosphatase SHP2
Jonathan R. LaRochelle,Michelle Fodor,Jana M. Ellegast,Xiaoxi Liu,Vidyasiri Vemulapalli,Morvarid Mohseni,Travis Stams,Sara J. Buhrlage,Kimberly Stegmaier,Matthew J. LaMarche,Michael G. Acker,Stephen C. Blacklow +11 more
TL;DR: This work employs high-throughput screening to discover a lead chemical scaffold, the benzothiazolopyrimidones, that allosterically inhibits this oncogenic phosphatase by simultaneously engaging the C-SH2 and PTP domains.
Journal ArticleDOI
CARM1 methylates MED12 to regulate its RNA-binding ability.
Donghang Cheng,Vidyasiri Vemulapalli,Yue Lu,Jianjun Shen,Sayura Aoyagi,Christopher J Fry,Yanzhong Yang,Charles E. Foulds,Fabio Stossi,Lindsey S. Treviño,Michael A. Mancini,Bert W. O'Malley,Cheryl Walker,Thomas G. Boyer,Mark T. Bedford +14 more
TL;DR: Ch Chromatin immunoprecipitation–seq studies revealed that CARM1 and the methyl mark it deposits are tightly associated with ERα-specific enhancers and positively modulate transcription of estrogen-regulated genes.