Vikash K. Sinha

TL;DR: The physiologically based pharmacokinetics (PBPK) model, which combined methods Vd2 and CL2 yielded the most accurate predictions of in vivo terminal half-life (69% within 2-fold), demonstrates that PBPK models can lead to reasonable predictions of human pharmacokinetic predictions.

TL;DR: In vivo methods performed slightly better than IVIVE methods (at least in terms of measures of correlation and global concordance), with the fu intercept method and two-species-based allometry (rat-dog) being the best performing methods.

TL;DR: The PBPK approach based on in vitro-input data was as accurate as the approachbased on in vivo data and the implications of compound properties are demonstrated.

TL;DR: Evaluated methodologies for the prediction of human volume of distribution at steady state with and without protein binding corrections found the top three methods that perform strongly at integrating in vivo data in this way were the Øie-Tozer, the rat -dog-human proportionality equation, and the lumped-PBPK approach.

TL;DR: The results illustrate that physiologically based prediction tools can provide accurate predictions of rat pharmacokinetics and Oral bioavailability was well predicted using CLh data and Gastroplus Software.