V
Vincent Schrijvers
Researcher at Flanders Institute for Biotechnology
Publications - 3
Citations - 2597
Vincent Schrijvers is an academic researcher from Flanders Institute for Biotechnology. The author has contributed to research in topics: Notch signaling pathway & APH-1. The author has an hindex of 2, co-authored 3 publications receiving 2516 citations.
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Journal ArticleDOI
A presenilin-1-dependent gamma-secretase-like protease mediates release of Notch intracellular domain.
Bart De Strooper,Wim Annaert,Philippe Cupers,Paul Saftig,Katleen Craessaerts,Jeff S. Mumm,Eric H. Schroeter,Vincent Schrijvers,Michael S. Wolfe,William J. Ray,Alison Goate,Raphael Kopan +11 more
TL;DR: It is reported that, in mammalian cells, PS1 deficiency also reduces the proteolytic release of NICD from a truncated Notch construct, thus identifying the specific biochemical step of the Notch signalling pathway that is affected by PS1.
Journal ArticleDOI
Presenilin 2 deficiency causes a mild pulmonary phenotype and no changes in amyloid precursor protein processing but enhances the embryonic lethal phenotype of presenilin 1 deficiency
An Herreman,Dieter H. Hartmann,Wim Annaert,Paul Saftig,Katleen Craessaerts,Lutgarde Serneels,Lieve Umans,Vincent Schrijvers,Frédéric Checler,Hugo Vanderstichele,Veerle Baekelandt,Ralf Dressel,Philippe Cupers,Danny Huylebroeck,An Zwijsen,Fred Van Leuven,Bart De Strooper +16 more
TL;DR: It is demonstrated in vivo that PS1 and PS2 have partially overlapping functions and thatPS1 is essential andPS2 is redundant for normal Notch signaling during mammalian embryological development.