V
Vincent Spegg
Researcher at University of Zurich
Publications - 9
Citations - 94
Vincent Spegg is an academic researcher from University of Zurich. The author has contributed to research in topics: Medicine & Biology. The author has an hindex of 3, co-authored 5 publications receiving 33 citations.
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Journal ArticleDOI
Kinase Interaction Network Expands Functional and Disease Roles of Human Kinases.
Marija Buljan,Marija Buljan,Rodolfo Ciuffa,Audrey van Drogen,Anton Vichalkovski,Martin Mehnert,George Rosenberger,George Rosenberger,Sohyon Lee,Markku Varjosalo,Lucia Espona Pernas,Vincent Spegg,Berend Snijder,Ruedi Aebersold,Ruedi Aebersold,Matthias Gstaiger +15 more
TL;DR: A comprehensive mass-spectrometry-based analysis of a human kinase interaction network covering more than 300 kinases is presented and dozens of kinase-disease associations spanning from genetic disorders to complex diseases, including cancer are uncovered.
Journal ArticleDOI
Phase separation properties of RPA combine high-affinity ssDNA binding with dynamic condensate functions at telomeres
Vincent Spegg,Andreas Panagopoulos,Merula Stout,Aswini R. Krishnan,Giordano Reginato,Ralph Imhof,Bernd Roschitzki,Petr Cejka,Matthias Altmeyer +8 more
TL;DR: In this article , the authors reveal that RPA has a strong propensity to assemble into dynamic condensates, and that the RPA phase separates into liquid droplets with fusion and surface wetting behavior.
Journal ArticleDOI
FAN1-MLH1 interaction affects repair of DNA interstrand cross-links and slipped-CAG/CTG repeats
Antonio Porro,Mohiuddin Mohiuddin,Christina Zurfluh,Vincent Spegg,Jingqi Dai,Florence Iehl,Virginie Ropars,Giulio Collotta,Keri M. Fishwick,Nour L. Mozaffari,Raphael Guerois,Josef Jiricny,Matthias Altmeyer,Jean-Baptiste Charbonnier,Christopher E. Pearson,Alessandro A. Sartori +15 more
TL;DR: In this article, the authors identify specific amino acid residues in two adjacent FAN1 motifs that are critical for MLH1 binding and demonstrate that FAN 1-S126 phosphorylation is a determinant of ICL response and repeat stability.
Journal ArticleDOI
Replicated chromatin curtails 53BP1 recruitment in BRCA1-proficient and BRCA1-deficient cells.
TL;DR: In this paper, a dual switch model from a 53BP1-dominated response in unreplicated chromatin to a BRCA1-BARD1 dominated response in replicated chromatin is presented.
Journal ArticleDOI
Biomolecular condensates at sites of DNA damage: More than just a phase
Vincent Spegg,Matthias Altmeyer +1 more
TL;DR: In this article, the authors discuss the cooperative potential between clustered stoichiometric binding and phase separation in the context of genome integrity maintenance and highlight the potential to balance structural specificity with favorable physicochemical properties relevant for the regulation and function of multilayered nuclear condensates.